Synthesis, characterization, and DNA binding study of ruthenium(II/III) complexes containing ONS donor Schiff base

被引：9

作者：

Singh, Anmol ^{[1
]}

Maiti, Subir Kr ^{[1
]}

Barman, Pranjit ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Silchar, Assam, India

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2021年 / 40卷 / 10期

关键词：

Schiff base; ruthenium; metal complex; octahedral; DNA binding; ANTIMICROBIAL ACTIVITY; MOLECULAR DOCKING; METAL-COMPLEXES; LIGAND; ANTIBACTERIAL; PHOTOCLEAVAGE; CYTOTOXICITY; ANTIFUNGAL; CLEAVAGE; SPECTRA;

D O I：

10.1080/15257770.2021.1969023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A chelating ligand of thioether with ONS donor Schiff base HL [(E)-2-(((2-(benzylthio)phenyl)imino)methyl)napthalen-1-ol] and its metal complexes (RuL1 and RuL2) have been synthesized. They have been characterized by UV-Vis, FTIR, H-1 NMR, C-13 NMR, mass spectrometry methods. The formulas of the synthesized compounds have been confirmed by elemental analysis and magnetic susceptibility measurements. The binding ability studies of the ligand (HL) and its Ru complexes (RuL1 and RuL2), with calf-thymus DNA have been explored by the absorption titration method. The binding interaction study reveals that the ligand (HL) and the complex RuL1 interact with CT-DNA through an intercalative mode of binding whereas the complex RuL2 does not show any interaction with CT-DNA due to steric effect.

引用

页码：968 / 984

页数：17

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