Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways

被引：23

作者：

Li, Ming ^{[1
]}

Li, Ping ^{[1
]}

Tang, Rongxue ^{[1
]}

Lu, Hui ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

来源：

FOOD SCIENCE AND HUMAN WELLNESS | 2022年 / 11卷 / 01期

关键词：

Resveratrol; Inflammatory bowel disease; Intestinal barrier; Gut microbiota; Inflammatory signaling pathways; KAPPA-B ACTIVATION; DIETARY RESVERATROL; ULCERATIVE-COLITIS; TRANS-RESVERATROL; DOUBLE-BLIND; METABOLISM; SUPPLEMENTATION; ANTIOXIDANT; APOPTOSIS; THERAPY;

D O I：

10.1016/j.fshw.2021.07.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Inflammatory bowel disease (IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. In this paper, we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier, regulating the unbalanced gut microbiota, and targeting various inflammatory signaling pathways. (C) 2021 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co, Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：22 / 31

页数：10

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