The Gut Microbiota in Inflammatory Bowel Disease

被引：66
|
作者：
Sheehan, Donal [1 ]
Shanahan, Fergus [1 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Dept Med, APC Microbiome Inst, Cork, Ireland
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 01期
基金：
爱尔兰科学基金会;
关键词：
Ulcerative colitis; Crohn's disease; Microbiota; Fecal microbial transplantation; Inflammatory bowel disease; INVASIVE E. COLI; ESCHERICHIA-COLI; TRANSPLANTATION; BACTERIOPHAGES; PATHOGENESIS; STIMULATION; DYSBIOSIS; AUTOPHAGY; FIBROSIS; VIROME;
D O I：
10.1016/j.gtc.2016.09.011
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Genes, bacteria, and immunity contribute to the pathogenesis of inflammatory bowel disease. Most genetic risk relates to defective sensing of microbes and their metabolites or defective regulation of the host response to the microbiota. Because the composition of the microbiota shapes the developing immune system and is determined in early life, the prospect of therapeutic manipulation of the microbiota in adulthood after the onset of disease is questionable. However, the microbiota may be a marker of risk and a modifier of disease activity and a contributor to extraintestinal manifestations and associations in some patients with inflammatory bowel disease.
引用
收藏
页码：143 / +
页数：13
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