Inflammatory bowel disease(IBD) is a chronic inflammatory lesion of the intestine, mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota. Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. Resveratrol is a natural polyphenol, and its various derivatives have anti-oxidation and anti-inflammatory properties. In this paper, we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier, regulating the unbalanced gut microbiota, and targeting various inflammatory signaling pathways.
机构:
Univ Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Tokyo, Japan
Chiba Univ, Med Mycol Res Ctr, Chiba, JapanUniv Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Tokyo, Japan
Goto, Yoshiyuki
Kurashima, Yosuke
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Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo, JapanUniv Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Tokyo, Japan
Kurashima, Yosuke
Kiyono, Hiroshi
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Univ Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Tokyo, Japan
Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo, JapanUniv Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Tokyo, Japan
机构:
Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, Japan
Matsuoka, Katsuyoshi
Kanai, Takanori
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Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, JapanKeio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, Japan
机构:
China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R ChinaChina Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Qiu, Peng
Ishimoto, Takatsugu
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机构:
Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Kumamoto, Japan
Kumamoto Univ, Int Res Ctr Med Sci, Gastrointestinal Canc Biol, Kumamoto, JapanChina Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Ishimoto, Takatsugu
Fu, Lingfeng
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机构:
Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Kumamoto, Japan
Kumamoto Univ, Int Res Ctr Med Sci, Gastrointestinal Canc Biol, Kumamoto, JapanChina Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Fu, Lingfeng
Zhang, Jun
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机构:
Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Kumamoto, Japan
Kumamoto Univ, Int Res Ctr Med Sci, Gastrointestinal Canc Biol, Kumamoto, JapanChina Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Zhang, Jun
Zhang, Zhenyong
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机构:China Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Zhang, Zhenyong
Liu, Yang
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机构:
China Med Univ, Dept Oncol, Shengjing Hosp, Shenyang, Peoples R ChinaChina Med Univ, Dept Anesthesiol, Shengjing Hosp, Shenyang, Peoples R China
Liu, Yang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
2022,
12