Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy

被引：9

作者：

Isaikina, N. V. ^{[1
]}

Kalinkina, G. I. ^{[1
]}

Razina, T. G. ^{[2
]}

Zueva, E. P. ^{[2
]}

Rybalkina, O. Yu. ^{[2
,3
]}

Ulirich, A. V. ^{[2
]}

Fedorova, E. P. ^{[2
]}

Shilova, A. B. ^{[1
]}

机构：

[1] Siberian State Med Univ, Tomsk 634050, Russia

[2] Russian Acad Sci, Tomsk Natl Res Med Ctr, ED Goldberg Sci Res Inst Pharmacol & Regenerat Me, Tomsk 634028, Russia

[3] Natl Res Tomsk State Univ, Tomsk 634050, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2018年 / 44卷 / 07期

关键词：

rowanberry fruit extracts; phenolic compounds; Lewis lung carcinoma; anthocyanins; antimetastatic activity; CELLS; GROWTH; BLUEBERRY; EXTRACTS;

D O I：

10.1134/S1068162018070038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The composition of phenolic compounds of rowanberry (Sorbus aucuparia L.) fruit extracts prepared with 40% ethanol and 95% acidified ethanol was studied. The differences in the content of flavonoids, including anthocyanins, and phenolic acids were shown. It was found that the antimetastatic activity of cyclophosphamide was most efficiently increased by the rowanberry fruit extract in 95% acidified ethanol enriched in anthocyanins. The aim of the present research was to investigate the effect of hydroalcoholic extracts of rowanberry fruit on the development of Lewis lung carcinoma and the antitumor activity of cyclophosphamide and to reveal the most effective extract containing a phenolic complex for its further study as a promising drug.

引用

页码：899 / 905

页数：7

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