Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

被引：12
|
作者：
Razina, T. G. [1 ]
Zueva, E. P. [1 ]
Ulrich, A. V. [1 ]
Rybalkina, O. Yu. [1 ,3 ]
Chaikovskii, A. V. [1 ]
Isaikina, N. V. [2 ]
Kalinkina, G. I. [2 ]
Zhdanov, V. V. [1 ]
Zyuz'kov, G. N. [1 ,3 ]
机构：
[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
[3] Natl Res Tomsk State Univ, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 162卷 / 01期
关键词：
Lewis lung carcinoma; B-16; melanoma; tumor stem cells; Fructus Sorbi aucupariae; anthocyans; MELANOMA-CELLS; INHIBITOR;
D O I：
10.1007/s10517-016-3554-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
引用
收藏
页码：93 / 97
页数：5
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