Mycobacterial purified protein derivatives stimulate innate immunity:: Malawians show enhanced tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-10 responses compared to those of adolescents in the United Kingdom

被引：18
|
作者：
Weir, RE
Black, GF
Dockrell, HM
Floyd, S
Fine, PEM
Chaguluka, SD
Stenson, S
King, E
Nazareth, B
Warndorff, DK
Ngwira, B
Crampin, AC
Mwaungulu, L
Sichali, L
Jarman, E
Donovan, L
Blackwell, JM
机构：
[1] Cambridge Inst Med Res, Wellcome Trust, Cambridge CB2 2XY, England
[2] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
[3] Redbridge & Waltham Forest Hlth Author, Ilford, England
[4] Karonga Prevent Study, Chilumba, Malawi
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期
关键词：
D O I：
10.1128/IAI.72.3.1807-1811.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interieukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
引用
收藏
页码：1807 / 1811
页数：5
相关论文
共 50 条
  • [41] SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 AND E-SELECTIN LEVELS IN PLASMA OF FALCIPARUM-MALARIA PATIENTS AND THEIR LACK OF CORRELATION WITH LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-ALPHA (IL-1-ALPHA), AND IL-10
    PEYRON, F
    CAUXMENETRIER, C
    ROUXLOMBARD, P
    NIYONGABO, T
    AUBRY, P
    DELORON, P
    CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1994, 1 (06) : 741 - 743
  • [42] ULTRAVIOLET (UV) B-INDUCED PROSTAGLANDIN (PG)-E2 SYNTHESIS OF HUMAN KERATINOCYTES (KC) IS MEDIATED BY THE COMBINED ACTION OF INTERLEUKIN-1 VIA THE TYPE-1 IL-1 RECEPTOR (IL-1 R) AND TUMOR-NECROSIS-FACTOR (TNF)ALPHA
    GYUFKO, K
    GREWE, M
    TREFZER, U
    BALLHORN, A
    HENNINGER, H
    KRUTMANN, J
    CLINICAL RESEARCH, 1993, 41 (02): : A501 - A501
  • [43] PREINCUBATION WITH INTERLEUKIN-1 (IL-1) AND TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) INCREASES THE SURVIVAL OF CD34+ CELLS AFTER TREATMENT WITH 4-HYDROPEROXYCYCLOPHOSPHAMIDE (4-HC)
    SAFAH, H
    GUEDEZ, L
    BRAYLAN, R
    ZUCALI, J
    MOREB, J
    BLOOD, 1993, 82 (10) : A652 - A652
  • [44] Short-term treatment of relapsing remitting multiple sclerosis patients with interferon (IFN)β1b transiently increases the blood levels of interleukin (IL)-6, IL-10 and IFN-γ without significantly modifying those of IL-1β, IL-2, IL-4 and tumour necrosis factor-α
    Nicoletti, F
    Di Marco, R
    Patti, F
    Zaccone, P
    L'Episcopo, MR
    Reggio, E
    Xiang, M
    Nicoletti, A
    Reggio, A
    CYTOKINE, 2000, 12 (06) : 682 - 687
  • [45] TUMOR-NECROSIS-FACTOR - ALPHA (TNF) STIMULATES FORMATION OF OSTEOCLAST-LIKE CELLS (OCL) IN LONG-TERM HUMAN MARROW CULTURES BY STIMULATING PRODUCTION OF INTERLEUKIN-1 (IL-1)
    ROODMAN, GD
    TAKAHASHI, N
    BIRD, A
    MUNDY, GR
    CLINICAL RESEARCH, 1987, 35 (03): : A515 - A515
  • [46] Strikingly higher interleukin (IL)-1α, IL-1β and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-α, transforming growth factor (TGF)-β2 and interferon IFN-γ urine levels in healthy females compared to healthy males:: protection against urinary tract injury?
    Sadeghi, M
    Daniel, V
    Naujokat, C
    Weimer, R
    Opelz, G
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 142 (02): : 312 - 317
  • [47] Absence of an association of tumor necrosis factor (TNF)-alpha G308A1 interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia
    Stonek, Felix
    Hafner, Erich
    Metzenbauer, Martin
    Katharina, Schuchter
    Stuempflen, Ingrid
    Schneeberger, Christian
    Zeisler, Harald
    Husslein, Peter
    Philipp, Karl
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 77 (01) : 85 - 90
  • [48] INCREASES IN LEVELS OF PROCOLLAGENASE MESSENGER-RNA IN FIBROBLASTS INDUCED BY INTERLEUKIN-1 (IL-1), TUMOR NECROSIS FACTOR (TNF-ALPHA) OR SERUM FOLLOW C-JUN EXPRESSION AND ARE DEPENDENT ON NEW PROTEIN-SYNTHESIS
    CONCA, W
    KAPLAN, PB
    KRANE, SM
    CLINICAL RESEARCH, 1989, 37 (02): : A613 - A613
  • [49] Interleukin-1 beta (IL-1β) induces tumor necrosis factor alpha (TNF-α) expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation
    Ledesma, E
    Martinez, I
    Córdova, Y
    Rodríguez-Sosa, M
    Monroy, A
    Mora, L
    Soto, I
    Ramos, G
    Weiss, B
    Santiago Osorio, E
    CYTOKINE, 2004, 26 (02) : 66 - 72
  • [50] RESPECTIVE EFFECTS OF SOLUBLE INTERLEUKIN-1 RECEPTOR AND TUMOR-NECROSIS-FACTOR RECEPTOR ON IL-1 AND TNF-ALPHA-INDUCED DNA-SYNTHESIS OF COMMON ACUTE LYMPHOBLASTIC-LEUKEMIA BLASTS IN-VITRO
    CARTER, A
    HADDAD, N
    DRAXLER, I
    ISRAELI, E
    RAZ, B
    TATARSKY, I
    BRITISH JOURNAL OF HAEMATOLOGY, 1994, 86 (01) : 22 - 29
12345