Mycobacterial purified protein derivatives stimulate innate immunity:: Malawians show enhanced tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-10 responses compared to those of adolescents in the United Kingdom

被引：18
|
作者：
Weir, RE
Black, GF
Dockrell, HM
Floyd, S
Fine, PEM
Chaguluka, SD
Stenson, S
King, E
Nazareth, B
Warndorff, DK
Ngwira, B
Crampin, AC
Mwaungulu, L
Sichali, L
Jarman, E
Donovan, L
Blackwell, JM
机构：
[1] Cambridge Inst Med Res, Wellcome Trust, Cambridge CB2 2XY, England
[2] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
[3] Redbridge & Waltham Forest Hlth Author, Ilford, England
[4] Karonga Prevent Study, Chilumba, Malawi
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期
关键词：
D O I：
10.1128/IAI.72.3.1807-1811.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interieukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
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页码：1807 / 1811
页数：5
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