Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

被引：1
|
作者：
Caceres, Diego H. [1 ]
Zuluaga, Alejandra [1 ]
Tabares, Angela M. [1 ]
Chiller, Tom [2 ]
Gonzalez, Angel [3 ]
Gomez, Beatriz L. [1 ,4 ]
机构：
[1] CIB, Med & Expt Mycol Grp, Medellin, Colombia
[2] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA
[3] Univ Antioquia, Escuela Microbiol, Grp Invest Microbiol Basica & Aplicada, Medellin, Colombia
[4] Univ Rosario, Escuela Med & Ciencias Salud, Bogota, Colombia
来源：
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2017年 / 59卷
关键词：
Cryptococcosis; Cryptococcus; Antigen; Diagnosis; Point-of-care; Lateral Flow Assay; Immunochromatographic assay; Latex agglutination system; IMMUNOASSAY;
D O I：
10.1590/S1678-9946201759076
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A Lateral Flow Assay to detect cryptococcal antigen (CrAg (R) LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg (R) LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS (R)) and CrAg (R) LFA was observed. CrAg (R) LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.
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页数：3
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