Carborane-linked 2′-deoxyuridine 5′-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA

被引：12

作者：

Balintova, Jana ^{[1
]}

Simonova, Anna ^{[1
]}

Bialek-Pietras, Magdalena ^{[2
]}

Olejniczak, Agnieszka ^{[2
]}

Lesnikowski, Zbigniew J. ^{[2
]}

Hocek, Michal ^{[1
,3
]}

机构：

[1] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, CZ-16610 Prague 6, Czech Republic

[2] Polish Acad Sci, Inst Med Biol, Lab Mol Virol & Biol Chem, 106 Lodowa St, PL-93232 Lodz, Poland

[3] Charles Univ Prague, Dept Organ Chem, Fac Sci, Hlavova 8, CZ-12843 Prague 2, Czech Republic

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 21期

关键词：

Nucleotides; Nucleoside triphosphates; Carboranes; DNA polymerase; Oligonucleotides; BORON CLUSTERS; 2'-DEOXYRIBONUCLEOSIDE TRIPHOSPHATES; NUCLEOTIDES; DERIVATIVES; DNTPS; DATP;

D O I：

10.1016/j.bmcl.2017.09.064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-[(p-Carborane-2-yl) ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4786 / 4788

页数：3

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