Carborane-linked 2′-deoxyuridine 5′-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA

被引：12
|
作者：
Balintova, Jana [1 ]
Simonova, Anna [1 ]
Bialek-Pietras, Magdalena [2 ]
Olejniczak, Agnieszka [2 ]
Lesnikowski, Zbigniew J. [2 ]
Hocek, Michal [1 ,3 ]
机构：
[1] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, CZ-16610 Prague 6, Czech Republic
[2] Polish Acad Sci, Inst Med Biol, Lab Mol Virol & Biol Chem, 106 Lodowa St, PL-93232 Lodz, Poland
[3] Charles Univ Prague, Dept Organ Chem, Fac Sci, Hlavova 8, CZ-12843 Prague 2, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 21期
关键词：
Nucleotides; Nucleoside triphosphates; Carboranes; DNA polymerase; Oligonucleotides; BORON CLUSTERS; 2'-DEOXYRIBONUCLEOSIDE TRIPHOSPHATES; NUCLEOTIDES; DERIVATIVES; DNTPS; DATP;
D O I：
10.1016/j.bmcl.2017.09.064
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
5-[(p-Carborane-2-yl) ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4786 / 4788
页数：3
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