Expression of Multidrug Efflux Pump Genes acrAB-tolC, mdfA, and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance

被引：158

作者：

Swick, Michelle C. ^{[1
,2
]}

Morgan-Linnell, Sonia K. ^{[1
]}

Carlson, Kimberly M. ^{[1
,3
]}

Zechiedrich, Lynn ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Interdept Program Cell & Mol Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 02期

关键词：

16S RIBOSOMAL-RNA; HYDROPHILIC FLUOROQUINOLONES; QEPA; AMINOGLYCOSIDES; METHYLATION; BACTERIA;

D O I：

10.1128/AAC.00996-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and acrB, and then mdfA and norE. Our findings suggest acrAB overexpression is an indicator of multidrug resistance.

引用

页码：921 / 924

页数：4

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