Efficacy and safety of high dose (≥ 8 mg/kg/day) daptomycin

被引：10
|
作者：
Parra-Ruiz, Jorge [1 ]
Pena-Monje, Alejandro [2 ]
Tomas-Jimenez, Cristina [1 ,3 ]
Pomares-Mora, Jose [4 ]
Hernandez-Quero, Jose [1 ]
机构：
[1] Hosp Univ San Cecilio, Unidad Enfermedades Infecciosas, Granada, Spain
[2] Hosp Univ San Cecilio, Microbiol Serv, Granada, Spain
[3] Hosp Univ Reina Sofia, Med Interna Serv, Murcia, Spain
[4] Hosp Univ San Cecilia, Serv Med Intens, Granada, Spain
来源：
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2011年 / 29卷 / 06期
关键词：
High dose daptomycin; Efficacy; Safety; SERUM;
D O I：
10.1016/j.eimc.2011.02.012
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: There is a paucity of data regarding efficacy and safety of high dose (> 8 mg/kg/day) daptomycin. Material and methods: This ambispective study included all patients that received >= 8 mg/kg/day of daptomycin and had efficacy and safety data. Results: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them. Conclusions: High dose daptomycin shows good efficacy without concerns about toxicity. (C) 2010 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：425 / 427
页数：3
相关论文
共 50 条
  • [41] Efficacy, safety, and pharmacokinetics of imatinib dose escalation to 800 mg/day in patients with advanced gastrointestinal stromal tumors
    Changhoon Yoo
    Min-Hee Ryu
    Baek-Yeol Ryoo
    Mo Youl Beck
    Yoon-Koo Kang
    Investigational New Drugs, 2013, 31 : 1367 - 1374
  • [42] Efficacy, safety, and pharmacokinetics of imatinib dose escalation to 800 mg/day in patients with advanced gastrointestinal stromal tumors
    Yoo, Changhoon
    Ryu, Min-Hee
    Ryoo, Baek-Yeol
    Beck, Mo Youl
    Kang, Yoon-Koo
    INVESTIGATIONAL NEW DRUGS, 2013, 31 (05) : 1367 - 1374
  • [43] Safety and efficacy of low-dose pioglitazone (7.5 mg/day) vs. standard-dose pioglitazone (15 mg/day) in Japanese women with type 2 diabetes mellitus
    Majima, Takafumi
    Komatsu, Yasato
    Doi, Kentaro
    Shigemoto, Michika
    Takagi, Chieko
    Fukao, Atsushi
    Corners, Jerry
    Nakao, Kazuwa
    ENDOCRINE JOURNAL, 2006, 53 (03) : 325 - 330
  • [44] Safety and efficacy of high-dose G-CSF (24 mcg/kg) for PBSC mobilisation in children
    Alcorta, I
    Estella, J
    Toll, T
    Rives, S
    Mateo, M
    BONE MARROW TRANSPLANTATION, 2001, 27 : S305 - S305
  • [45] Minidex: very low dose dexamethasone (0.05 mg/kg/day) in chronic lung disease
    Yates, H. L.
    Newell, S. J.
    ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2011, 96 (03): : F190 - F194
  • [46] Efficacy, safety, and tolerability of desvenlafaxine 50 mg/day and 100 mg/day in outpatients with major depressive disorder
    Liebowitz, Michael R.
    Manley, Amy L.
    Padmanabhan, Sudharshan K.
    Ganguly, Rita
    Tummala, Raj
    Tourian, Karen A.
    CURRENT MEDICAL RESEARCH AND OPINION, 2008, 24 (07) : 1877 - 1890
  • [47] Safety of treatment with high-dose daptomycin in 102 patients with infective endocarditis
    Durante-Mangoni, Emanuele
    Andini, Roberto
    Parrella, Antonio
    Mattucci, Irene
    Cavezza, Giusi
    Senese, Alessandra
    Trojaniello, Claudia
    Caprioli, Roberta
    Diana, Maria Veronica
    Utili, Riccardo
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2016, 48 (01) : 61 - 68
  • [48] SINGLE-DOSE PHARMACOKINETICS AND TOLERABILITY OF DAPTOMYCIN 8 TO 10 MG/KG IN CHILDREN AGED 2 TO 6 YEARS WITH SUSPECTED OR PROVED GRAM-POSITIVE INFECTIONS
    Abdel-Rahman, Susan M.
    Chandorkar, Gurudatt
    Akins, Ronda L.
    Bradley, John S.
    Jacobs, Richard F.
    Donovan, Julie
    Benziger, David P.
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (08) : 712 - 714
  • [49] COMPARISON OF SIDE-EFFECTS AND HEMODYNAMIC-CHANGES WITH HIGH-DOSE (0.84 MG KG) VS STANDARD DOSE (0.56 MG KG) DIPYRIDAMOLE
    NAGARAJ, N
    GERSON, MC
    MAXON, HR
    JOURNAL OF NUCLEAR MEDICINE, 1993, 34 (05) : P152 - P152
  • [50] A Multicentre Randomized Controlled Trial of the Efficacy and Safety of Single-Dose Praziquantel at 40 mg/kg vs. 60 mg/kg for Treating Intestinal Schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil
    Olliaro, Piero L.
    Vaillant, Michel T.
    Belizario, Vincente J.
    Lwambo, Nicholas J. S.
    Ouldabdallahi, Mohamed
    Pieri, Otavio S.
    Amarillo, Maria L.
    Kaatano, Godfrey M.
    Diaw, Mamadou
    Domingues, AnaLucia C.
    Favre, Tereza C.
    Lapujade, Olivier
    Alves, Fabiana
    Chitsulo, Lester
    PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (06)
12345