Efficacy and safety of high dose (≥ 8 mg/kg/day) daptomycin

被引：10

作者：

Parra-Ruiz, Jorge ^{[1
]}

Pena-Monje, Alejandro ^{[2
]}

Tomas-Jimenez, Cristina ^{[1
,3
]}

Pomares-Mora, Jose ^{[4
]}

Hernandez-Quero, Jose ^{[1
]}

机构：

[1] Hosp Univ San Cecilio, Unidad Enfermedades Infecciosas, Granada, Spain

[2] Hosp Univ San Cecilio, Microbiol Serv, Granada, Spain

[3] Hosp Univ Reina Sofia, Med Interna Serv, Murcia, Spain

[4] Hosp Univ San Cecilia, Serv Med Intens, Granada, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2011年 / 29卷 / 06期

关键词：

High dose daptomycin; Efficacy; Safety; SERUM;

D O I：

10.1016/j.eimc.2011.02.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: There is a paucity of data regarding efficacy and safety of high dose (> 8 mg/kg/day) daptomycin. Material and methods: This ambispective study included all patients that received >= 8 mg/kg/day of daptomycin and had efficacy and safety data. Results: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them. Conclusions: High dose daptomycin shows good efficacy without concerns about toxicity. (C) 2010 Elsevier Espana, S.L. All rights reserved.

引用

页码：425 / 427

页数：3

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