Efficacy and safety of high dose (≥ 8 mg/kg/day) daptomycin

被引：10
|
作者：
Parra-Ruiz, Jorge [1 ]
Pena-Monje, Alejandro [2 ]
Tomas-Jimenez, Cristina [1 ,3 ]
Pomares-Mora, Jose [4 ]
Hernandez-Quero, Jose [1 ]
机构：
[1] Hosp Univ San Cecilio, Unidad Enfermedades Infecciosas, Granada, Spain
[2] Hosp Univ San Cecilio, Microbiol Serv, Granada, Spain
[3] Hosp Univ Reina Sofia, Med Interna Serv, Murcia, Spain
[4] Hosp Univ San Cecilia, Serv Med Intens, Granada, Spain
来源：
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2011年 / 29卷 / 06期
关键词：
High dose daptomycin; Efficacy; Safety; SERUM;
D O I：
10.1016/j.eimc.2011.02.012
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: There is a paucity of data regarding efficacy and safety of high dose (> 8 mg/kg/day) daptomycin. Material and methods: This ambispective study included all patients that received >= 8 mg/kg/day of daptomycin and had efficacy and safety data. Results: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them. Conclusions: High dose daptomycin shows good efficacy without concerns about toxicity. (C) 2010 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：425 / 427
页数：3
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