Non-transferrin-bound iron during allogeneic stem cell transplantation

被引：121
|
作者：
Sahlstedt, L
Ebeling, F
von Bonsdorff, L
Parkkinen, J
Ruutu, T
机构：
[1] Univ Helsinki, Cent Hosp, Dept Med, FIN-00029 Helsinki, Finland
[2] Finnish Red Cross, Blood Transfus Serv, Helsinki, Finland
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 03期
关键词：
NTBI; iron; transferrin saturation; stem cell transplantation; bleomycin-detectable iron;
D O I：
10.1046/j.1365-2141.2001.02820.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained >80% thereafter. NTBI, measured as bleomycin-detectable iron, was detected for 6-18 d in all patients with a peak on d -4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity.
引用
收藏
页码：836 / 838
页数：3
相关论文
共 50 条
  • [41] Lack of Non-Transferrin-Bound Iron in Heart Transplant Recipients
    Przybylowski, P.
    Malyszko, J.
    Levin-Iaina, N.
    Malyszko, J. S.
    TRANSPLANTATION PROCEEDINGS, 2011, 43 (08) : 3068 - 3070
  • [42] NON-TRANSFERRIN-BOUND IRON UPTAKE BY ISOLATED RAT HEPATOCYTES
    BARISANI, D
    BERG, CL
    WESSLINGRESNICK, M
    GOLLAN, JL
    GASTROENTEROLOGY, 1994, 106 (04) : A864 - A864
  • [43] Is myocardial accumulation of non-transferrin-bound iron clinically relevant?
    von Haehling, Stephan
    Sato, Ryosuke
    Anker, Stefan D.
    EUROPEAN HEART JOURNAL, 2024, 45 (42) : 4509 - 4511
  • [44] PROPERTIES AND HEPATIC-METABOLISM OF NON-TRANSFERRIN-BOUND IRON
    BATEY, RG
    SHAMIR, S
    WILMS, J
    DIGESTIVE DISEASES AND SCIENCES, 1981, 26 (12) : 1084 - 1088
  • [45] Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron
    Eur J Biochem, 2 (463):
  • [46] Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron
    Callus, BA
    Iacopetta, BJ
    Kuhn, LC
    Morgan, EH
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 238 (02): : 463 - 469
  • [47] Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease
    Marwah, SS
    Wheelwright, D
    Blann, AD
    Rea, C
    Beresford, R
    Phillips, JD
    Wright, J
    Bareford, D
    BRITISH JOURNAL OF HAEMATOLOGY, 2001, 114 (04) : 917 - 919
  • [48] Non-transferrin-bound iron in plasma following administration of oral iron drugs
    Bernd Dresow
    Doerte Petersen
    Roland Fischer
    Peter Nielsen
    BioMetals, 2008, 21 : 273 - 276
  • [49] Changes in non-transferrin-bound iron (NTBI) in pregnant women on iron supplements
    Baron, Joel
    Ben-David, Gila
    Hallak, Mordechai
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2008, 140 (02) : 281 - 282
  • [50] Non-Transferrin-Bound Iron Serves As Iron Source for Aspergillus Fumigatus Growth
    Petzer, Verena
    Tymoszuk, Piotr
    Seifert, Markus
    Orth-Holler, Dorothea
    Wermke, Martin
    Platzbecker, Uwe
    Weiss, Gunter
    Haas, Hubertus
    Theurl, Igor
    BLOOD, 2017, 130
12345