Non-transferrin-bound iron during allogeneic stem cell transplantation

被引：121
|
作者：
Sahlstedt, L
Ebeling, F
von Bonsdorff, L
Parkkinen, J
Ruutu, T
机构：
[1] Univ Helsinki, Cent Hosp, Dept Med, FIN-00029 Helsinki, Finland
[2] Finnish Red Cross, Blood Transfus Serv, Helsinki, Finland
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 03期
关键词：
NTBI; iron; transferrin saturation; stem cell transplantation; bleomycin-detectable iron;
D O I：
10.1046/j.1365-2141.2001.02820.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained >80% thereafter. NTBI, measured as bleomycin-detectable iron, was detected for 6-18 d in all patients with a peak on d -4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity.
引用
收藏
页码：836 / 838
页数：3
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