In China nowadays, some enterprises begin to develop the sustainable supply chain (S-SC) because of the strengthening of environment regulations. How to deal with certain multi-criteria decision-making problems effectively and efficiently is the key for the development of S-SC. In this paper, the main factors and their relationship during the operation of S-SC were analyzed, and combined with the analytic network approach, an integrative decision-making model was proposed to handle different kinds of decision-making problems. The decision-making process combined with a simple example was also given to describe the application of the proposed model. The conclusions are helpful to guide the construction and operation of S-SC by decision-makers. (C) 2011 Published by Elsevier Ltd. Selection and peer-review under responsibility of RIUDS