Vasorelaxing alkaloids and flavonoids from Cassytha filiformis

被引：36
|
作者：
Tsai, Tung-Hu [1 ,2 ]
Wang, Guei-Jane [3 ]
Lin, Lie-Chwen [1 ,3 ]
机构：
[1] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan
[2] Taipei City Hosp, Renai Branch, Dept Educ & Res, Taipei, Taiwan
[3] Natl Res Inst Chinese Med, Taipei, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期
关键词：
D O I：
10.1021/np070564h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new aporphine alkaloids, isofiliformine (1) and cassythic acid (3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid (3), cassythine (4), neolitsine (7), and dicentrine (8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC50 values between 0.08 and 2.48 mu M. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyapotphine (2), (-)-O-methylflavinatine (10), (-)-salutaridine (11), isohamnetin-3-O-beta-glucoside, and isohamnetin-3-O-rutinoside exerted moderate vessel-relaxing activities with IC50 values from 16.50 to 32.81 mu M at the test concentrations.
引用
收藏
页码：289 / 291
页数：3
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