Vasorelaxing alkaloids and flavonoids from Cassytha filiformis

被引：36
|
作者：
Tsai, Tung-Hu [1 ,2 ]
Wang, Guei-Jane [3 ]
Lin, Lie-Chwen [1 ,3 ]
机构：
[1] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan
[2] Taipei City Hosp, Renai Branch, Dept Educ & Res, Taipei, Taiwan
[3] Natl Res Inst Chinese Med, Taipei, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 02期
关键词：
D O I：
10.1021/np070564h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new aporphine alkaloids, isofiliformine (1) and cassythic acid (3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid (3), cassythine (4), neolitsine (7), and dicentrine (8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC50 values between 0.08 and 2.48 mu M. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyapotphine (2), (-)-O-methylflavinatine (10), (-)-salutaridine (11), isohamnetin-3-O-beta-glucoside, and isohamnetin-3-O-rutinoside exerted moderate vessel-relaxing activities with IC50 values from 16.50 to 32.81 mu M at the test concentrations.
引用
收藏
页码：289 / 291
页数：3
相关论文
共 50 条
  • [31] MORPHOGENIC INVESTIGATIONS ON PARASITIC ANGIOSPERMS .3. CASSYTHA-FILIFORMIS (LAURACEAE)
    RANGAN, TS
    RANGASWA.NS
    PHYTOMORPHOLOGY, 1969, 19 (03): : 292 - &
  • [32] Gelsemium poisoning in a family after consumption of Cassytha filiformis Linn. collected in the countryside
    Lam, P. K.
    Au, T. T. S.
    Leung, J. K. S.
    Wong, T. W.
    HONG KONG JOURNAL OF EMERGENCY MEDICINE, 2015, 22 (01) : 60 - 63
  • [33] Pharmacological evaluation of ocoteine, isolated from Cassytha filiformis, as an alpha(1)-adrenoceptor antagonist in rat thoracic aorta
    Chang, CW
    Ko, FN
    Su, MJ
    Wu, YC
    Teng, CM
    JAPANESE JOURNAL OF PHARMACOLOGY, 1997, 73 (03): : 207 - 214
  • [34] FLAVONOIDS AND ALKALOIDS FROM CHAMAECYTISUS ERIOCARPUS
    DAMADYAN, B
    GUNER, N
    MERICLI, AH
    CUBUKCU, B
    PLANTA MEDICA, 1986, (06) : 504 - 504
  • [35] Alkaloids and flavonoids from peanut skins
    Lou, HX
    Yuan, HQ
    Yamazaki, Y
    Sasaki, T
    Oka, SC
    PLANTA MEDICA, 2001, 67 (04) : 345 - 349
  • [36] Alkaloids and Flavonoids from Polyalthia cauliflora
    Wan Mohd Nuzul Hakimi Wan Salleh
    Natasa Mohd Shakri
    Muhammad Haffiz Jauri
    Mohd Azlan Nafiah
    Chemistry of Natural Compounds, 2022, 58 : 986 - 988
  • [37] Alkaloids and Flavonoids from Illigera aromatica
    Zhang, Xin
    Zhang, Hai-Jiang
    Ge, Yi-Chao
    Wang, Kui-Wu
    CHEMISTRY OF NATURAL COMPOUNDS, 2020, 56 (03) : 580 - 582
  • [38] FLAVONOIDS AND ALKALOIDS FROM CUSCUTA (CUSCUTACEAE)
    GARCIA, MR
    ERAZO, SG
    PENA, RC
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1995, 23 (05) : 571 - 572
  • [39] Alkaloids and Flavonoids from Illigera aromatica
    Xin Zhang
    Hai-Jiang Zhang
    Yi-Chao Ge
    Kui-Wu Wang
    Chemistry of Natural Compounds, 2020, 56 : 580 - 582
  • [40] ALKALOIDS AND FLAVONOIDS FROM Polyalthia cauliflora
    Salleh, Wan Mohd Nuzul Hakimi Wan
    Shakri, Natasa Mohd
    Jauri, Muhammad Haffiz
    Nafiah, Mohd Azlan
    CHEMISTRY OF NATURAL COMPOUNDS, 2022, 58 (05) : 986 - 988
12345