Mining cancer gene expression databases for latent information on intronic microRNAs

被引:4
|
作者
Monterisi, Simona [1 ]
D'Ario, Giovanni [1 ]
Dama, Elisa [1 ,2 ]
Rotmensz, Nicole [2 ]
Confalonieri, Stefano [1 ,3 ]
Tordonato, Chiara [1 ]
Troglio, Flavia [1 ]
Bertalot, Giovanni [1 ]
Maisonneuve, Patrick [2 ]
Viale, Giuseppe [4 ,5 ]
Nicassio, Francesco [1 ,3 ,6 ]
Vecchi, Manuela [1 ,3 ]
Di Fiore, Pier Paolo [1 ,3 ,7 ]
Bianchi, Fabrizio [1 ]
机构
[1] European Inst Oncol, Dept Expt Oncol, Program Mol Med, I-20141 Milan, Italy
[2] European Inst Oncol, Div Epidemiol & Biostat, I-20141 Milan, Italy
[3] FIRC Inst Mol Oncol Fdn, IFOM, Milan, Italy
[4] European Inst Oncol, Div Pathol, I-20141 Milan, Italy
[5] Univ Milan, Sch Med, Milan, Italy
[6] Ist Italian Tecnol, Ctr Genom Sci IIT SEMM, Milan, Italy
[7] Univ Milan, Dept Sci Salute, Milan, Italy
基金
欧洲研究理事会;
关键词
MicroRNA; Cancer; Gene expression; Breast cancer; LARGE-T-ANTIGEN; BREAST-CANCER; HISTOLOGIC GRADE; HOST GENES; CELL; PROGNOSIS; CLASSIFICATION; IDENTIFICATION; PROFILES; SUBTYPES;
D O I
10.1016/j.molonc.2014.10.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Around 50% of all human microRNAs reside within introns of coding genes and are usually co-transcribed. Gene expression datasets, therefore, should contain a wealth of miRNA-relevant latent information, exploitable for many basic and translational research aims. The present study was undertaken to investigate this possibility. We developed an in silico approach to identify intronic-miRNAs relevant to breast cancer, using public gene expression datasets. This led to the identification of a miRNA signature for aggressive breast cancer, and to the characterization of novel roles of selected miRNAs in cancer-related biological phenotypes. Unexpectedly, in a number of cases, expression regulation of the intronic-miRNA was more relevant than the expression of their host gene. These results provide a proof of principle for the validity of our intronic miRNA mining strategy, which we envision can be applied not only to cancer research, but also to other biological and biomedical fields. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:473 / 487
页数:15
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