Identification, Synthesis and SAR Investigation of a Series of Novel Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators

被引：0
|
作者：
Duvey, G. [1 ]
Perry, B. [1 ]
Pesenti, C. [2 ]
Charvin, D. [1 ]
Lambeng, N. [1 ]
Donovan-Rodriguez, T. [1 ]
Poli, S. [1 ]
Le Poul, E. [1 ]
Gagliardi, S. [2 ]
Bonnet, B. [1 ]
机构：
[1] Addex Pharmaceut, CH-1228 Geneva, Switzerland
[2] NIKEM Res Srl, I-20021 Baranzate Di Bollate, MI, Italy
来源：
CURRENT NEUROPHARMACOLOGY | 2011年 / 9卷
关键词：
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
45
引用
收藏
页码：17 / 17
页数：1
相关论文
共 50 条
  • [41] Efficacy switching SAR of mGluR5 allosteric modulators: Highly potent positive and negative modulators from one chemotype
    Sams, Anette Graven
    Mikkelsen, Gitte Kobberoe
    Brodbeck, Robbin M.
    Pu, Xiaosui
    Ritzen, Andreas
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (11) : 3407 - 3410
  • [42] Allosteric Modulators of Metabotropic Glutamate Receptor 5 for Treatment of Schizophrenia
    Conn, P. J.
    Stauffer, S. R.
    Zhou, S.
    Manka, J.
    Williams, R.
    Noetzel, M. J.
    Gregory, K. J.
    Vinson, P.
    Niswender, C. M.
    Jones, C. K.
    Steckler, T.
    MacDonald, G.
    Lindsley, C. W.
    CURRENT NEUROPHARMACOLOGY, 2011, 9 : 11 - 12
  • [43] Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5
    Jong, Yuh-Jiin I.
    O'Malley, Karen L.
    NEUROCHEMICAL RESEARCH, 2017, 42 (01) : 166 - 172
  • [44] Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators
    Kos, Jackson A.
    Langiu, Monica
    Hellyer, Shane D.
    Gregory, Karen J.
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2024,
  • [45] Characterization of antibodies directed against metabotropic glutamate receptor mGluR5
    Richmond, SA
    Hargreaves, AC
    Doherty, AJ
    Bruton, R
    Collingridge, GL
    Henley, JM
    BRITISH JOURNAL OF PHARMACOLOGY, 1996, 119 : P253 - P253
  • [46] Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
    Kampen, Stefanie
    Rodriguez, David
    Jorgensen, Morten
    Kruszyk-Kujawa, Monika
    Huang, Xinyan
    Collins, Michael, Jr.
    Boyle, Noel
    Maurel, Damien
    Rudling, Axel
    Lebon, Guillaume
    Carlsson, Jens
    ACS CHEMICAL BIOLOGY, 2022, 17 (10) : 2744 - 2752
  • [47] Design and synthesis of novel metabotropic glutamate receptor allosteric modulators
    Stankiewicz, Anna
    Bugno, Ryszard
    Branski, Piotr
    Bojarski, Andrzej J.
    PHARMACOLOGICAL REPORTS, 2012, 64 (02) : 473 - 474
  • [48] Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators
    Shah, Falgun
    Stepan, Antonia F.
    O'Mahony, Alison
    Velichko, Sharlene
    Folias, Alexandra E.
    Houle, Christopher
    Shaffer, Christopher L.
    Marcek, John
    Whritenour, Jessica
    Stanton, Robert
    Berg, Ellen L.
    CELL CHEMICAL BIOLOGY, 2017, 24 (07): : 858 - +
  • [49] Design and synthesis of novel metabotropic glutamate receptor allosteric modulators
    Anna Stankiewicz
    Ryszard Bugno
    Piotr Brański
    Andrzej J. Bojarski
    Pharmacological Reports, 2012, 64 : 473 - 474
  • [50] Crystal structure of a class C GPCR - metabotropic Glutamate receptor 5 (mGluR5)
    Dore, A. S.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015, 44 : S201 - S201
12345