Identification, Synthesis and SAR Investigation of a Series of Novel Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators

被引：0
|
作者：
Duvey, G. [1 ]
Perry, B. [1 ]
Pesenti, C. [2 ]
Charvin, D. [1 ]
Lambeng, N. [1 ]
Donovan-Rodriguez, T. [1 ]
Poli, S. [1 ]
Le Poul, E. [1 ]
Gagliardi, S. [2 ]
Bonnet, B. [1 ]
机构：
[1] Addex Pharmaceut, CH-1228 Geneva, Switzerland
[2] NIKEM Res Srl, I-20021 Baranzate Di Bollate, MI, Italy
来源：
CURRENT NEUROPHARMACOLOGY | 2011年 / 9卷
关键词：
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
45
引用
收藏
页码：17 / 17
页数：1
相关论文
共 50 条
  • [31] Recent progress in the discovery and development of negative allosteric modulators of mGluR5
    Lindsley, Craig W.
    Emmitte, Kyle A.
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2009, 12 (04) : 446 - 457
  • [32] Process research and development of BMS-955829, a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5)
    Bobes, Francisco Gonzalez
    Strotman, Neil
    Ronald, Hanson
    Goswami, Animesh
    Guo, Zhiwei
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [33] Identification of alpha-substituted acylamines as novel, potent, and orally active mGluR5 negative allosteric modulators
    Yoshikawa, Keita
    Ohyama, Tomofumi
    Takahashi, Eiki
    Numajiri, Yoshitaka
    Konno, Mitsuhiro
    Moriyama, Masaki
    Takemi, Natsumi
    Kunita, Kana
    Nishimura, Kazumi
    Hayashi, Ryoji
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (16) : 3135 - 3141
  • [34] Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
    Lee, Jeong Ho
    Lee, Jinu
    Choi, Kyu Yeong
    Hepp, Regine
    Lee, Jae-Youn
    Lim, Mi Kyung
    Chatani-Hinze, Mayumi
    Roche, Paul A.
    Kim, Dong Goo
    Ahn, Young Soo
    Kim, Chul Hoon
    Roche, Katherine W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (34) : 12575 - 12580
  • [35] Metabotropic glutamate receptor mGluR5: a key regulator of neuronal selection?
    Copani, A
    Casabona, G
    Bruno, V
    Parenti, R
    Cicirata, F
    Knopfel, T
    Kuhn, R
    Nicoletti, F
    METABOTROPIC GLUTAMATE RECEPTORS AND BRAIN FUNCTION, 1998, 12 : 215 - 223
  • [36] Expression of Metabotropic Glutamate Receptor mGluR5 in Human Dental Pulp
    Kim, Yun Sook
    Kim, Young Jae
    Paik, Sang Kyoo
    Cho, Yi Sul
    Kwon, Tae Geon
    Ahn, Dong Kuk
    Kim, Sung Kyo
    Yoshida, Atsushi
    Bae, Yong Chul
    JOURNAL OF ENDODONTICS, 2009, 35 (05) : 690 - 694
  • [37] Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response
    Calcinaghi, Novella
    Jolivet, Renaud
    Wyss, Matthias T.
    Ametamey, Simon M.
    Gasparini, Fabrizio
    Buck, Alfred
    Weber, Bruno
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (09): : 1967 - 1967
  • [38] Tyrosine phosphorylation of the metabotropic glutamate receptor mGluR5 in striatal neurons
    Orlando, LR
    Dunah, AW
    Standaert, DG
    Young, AB
    NEUROPHARMACOLOGY, 2002, 43 (02) : 161 - 173
  • [39] Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5
    Yuh-Jiin I. Jong
    Karen L. O’Malley
    Neurochemical Research, 2017, 42 : 166 - 172
  • [40] Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
    Varnes, Jeffrey G.
    Marcus, Andrew P.
    Mauger, Russell C.
    Throner, Scott R.
    Hoesch, Valerie
    King, Megan M.
    Wang, Xia
    Sygowski, Linda A.
    Spear, Nathan
    Gadient, Reto
    Brown, Dean G.
    Campbell, James B.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (05) : 1402 - 1406
12345