Plasma Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk

被引：59

作者：

Eussen, Simone J. P. M. ^{[1
]}

Vollset, Stein Emil ^{[3
,4
]}

Hustad, Steinar ^{[2
]}

Midttun, Oivind ^{[5
]}

Meyer, Klaus ^{[5
]}

Fredriksen, Ase ^{[5
]}

Ueland, Per Magne ^{[5
]}

Jenab, Mazda ^{[6
]}

Slimani, Nadia ^{[6
]}

Boffetta, Paolo ^{[6
]}

Overvad, Kim ^{[7
]}

Thorlacius-Ussing, Ole ^{[8
]}

Tjonneland, Anne ^{[9
]}

Olsen, Anja ^{[9
]}

Clavel-Chapelon, Francoise ^{[10
,11
]}

Boutron-Ruault, Marie-Christine ^{[10
,11
]}

Morois, Sophie ^{[10
,11
]}

Weikert, Cornelia ^{[12
]}

Pischon, Tobias ^{[12
]}

Linseisen, Jakob ^{[13
,14
]}

Kaaks, Rudolf ^{[13
]}

Trichopoulou, Antonia ^{[15
]}

Zilis, Demosthenes ^{[15
]}

Katsoulis, Michael ^{[15
]}

Palli, Domenico ^{[16
]}

Pala, Valeria ^{[17
]}

Vineis, Paolo ^{[18
,36
]}

Tumino, Rosario ^{[19
]}

Panico, Salvatore ^{[20
]}

Peeters, Petra H. M. ^{[21
,36
]}

Bueno-de-Mesquita, H. Bas ^{[22
]}

van Duijnhoven, Franzel J. B. ^{[22
]}

Skeie, Guri ^{[23
]}

Munoz, Xavier ^{[24
,25
]}

Martinez, Carmen ^{[26
]}

Dorronsoro, Miren ^{[27
]}

Ardanaz, Eva ^{[28
]}

Navarro, Carmen ^{[29
]}

Rodriguez, Laudina ^{[30
]}

VanGuelpen, Bethany ^{[31
]}

Palmqvist, Richard ^{[31
]}

Manjer, Jonas ^{[32
]}

Ericson, Ulrika ^{[33
]}

Bingham, Sheila ^{[34
,35
]}

Khaw, Kay-Tee ^{[34
,35
]}

Norat, Teresa ^{[36
]}

Riboli, Elio ^{[36
]}

机构：

[1] Univ Bergen, Dept Internal Med, Pharmacol Sect, LOCUS Homocysteine & Related Vitamins,Inst Med, Bergen, Norway

[2] Haukeland Hosp, Hormone Lab, N-5021 Bergen, Norway

[3] Med Birth Registry, Bergen, Norway

[4] Norwegian Inst Publ Hlth & Primary Hlth Care, Bergen, Norway

[5] Bevital AS, Bergen, Norway

[6] Int Agcy Res Canc IARC WHO, Lyon, France

[7] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[8] Aarhus Univ Hosp, Aalborg Hosp, Dept Surg Gastroenterol, Aalborg, Denmark

[9] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[10] INSERM, Villejuif, France

[11] Inst Gustave Roussy, Villejuif, France

[12] German Inst Human Nutr, Dept Epidemiol, Potsdam, Nuthetal, Germany

[13] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[14] German Res Ctr Environm Hlth HMGU, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany

[15] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[16] ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[17] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[18] Univ Turin, Dept Biomed Sci, Turin, Italy

[19] Canc Registry Azienda Osped Civile MP Arezzo, Ragusa, Italy

[20] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[21] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[22] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[23] Univ Tromso, Inst Community Med, Tromso, Norway

[24] IDIBELL Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain

[25] IDIBELL Catalan Inst Oncol, Translat Res Lab, Barcelona, Spain

[26] Andalusian Sch Publ Hlth, Granada, Spain

[27] Dept Publ Hlth Guipuzkoa, San Sebastian, Spain

[28] Publ Hlth Inst Navarra, Pamplona, Spain

[29] Hlth Council Murcia, Dept Epidemiol, Murcia, Spain

[30] Hlth & Hlth Care Serv Council, Publ Hlth Directorate, Asturias, Spain

[31] Umea Univ, Dept Med Biosci, Umea, Sweden

[32] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[33] Lund Univ, Dept Clin Sci Malmo Nutr Epidemiol, S-22100 Lund, Sweden

[34] MRC Dunn Human Nutr Unit, Cambridge, England

[35] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England

[36] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2010年 / 19卷 / 10期

关键词：

ONE-CARBON METABOLISM; METHIONINE SYNTHASE GENE; METHYLENETETRAHYDROFOLATE REDUCTASE; FOLATE METABOLISM; MASS-SPECTROMETRY; HOMOCYSTEINE METABOLISM; DNA METHYLATION; DIETARY-INTAKE; RAT-LIVER; POLYMORPHISMS;

D O I：

10.1158/1055-9965.EPI-10-0407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; P-trend = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; P-trend <0.001) for vitamin B6, and 1.02 (95% CI, 0.80-1.29; P-trend = 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >= 30 g alcohol/day. The polymorphisms were not associated with colorectal cancer. Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549-61. (C) 2010 AACR.

引用

页码：2549 / 2561

页数：13

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