Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities

被引：8

作者：

Kang, Qian-jin ^{[1
,3
]}

Yang, Xian-wen ^{[1
,2
]}

Wu, Shao-hua ^{[1
]}

Ma, Yan-ling ^{[4
]}

Li, Ling ^{[4
]}

Shen, Yue-mao ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Dep Nat Prod Chem, Shanghai, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China

[4] Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China

来源：

PLANTA MEDICA | 2008年 / 74卷 / 04期

关键词：

Trewia nudiflora; Euphorbiaceae; stem bark; antioxidant activities;

D O I：

10.1055/s-2008-1034361

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4-O-beta-(6"-O-galloyl)-glucopyranoside (1), 4,4'-O-dimethylellagic acid 3-(2"-O-acetyl)-alpha-rhamnopyranoside (2), and ethyl O-beta-(6'-galloyl)-glucopyranoside (3), together with eleven known ones, were isolated from the stem bark of Trewia nudiflora. Their structures were elucidated by means of I D, 2 D NMR and HR-MS analyses. The antioxidant activities of these compounds were evaluated with the DPPH radical-scavenging assay. Compound 1 showed significant antioxidant activity. In addition, compounds 1, 2 and 3 rescued the H2O2-induced PC12 cell death at 0.4 mu M in the MTT assay.

引用

页码：445 / 448

页数：4

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