Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities

被引：8
|
作者：
Kang, Qian-jin [1 ,3 ]
Yang, Xian-wen [1 ,2 ]
Wu, Shao-hua [1 ]
Ma, Yan-ling [4 ]
Li, Ling [4 ]
Shen, Yue-mao [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Second Mil Med Univ, Sch Pharm, Dep Nat Prod Chem, Shanghai, Peoples R China
[3] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
[4] Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming, Peoples R China
来源：
PLANTA MEDICA | 2008年 / 74卷 / 04期
关键词：
Trewia nudiflora; Euphorbiaceae; stem bark; antioxidant activities;
D O I：
10.1055/s-2008-1034361
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4-O-beta-(6"-O-galloyl)-glucopyranoside (1), 4,4'-O-dimethylellagic acid 3-(2"-O-acetyl)-alpha-rhamnopyranoside (2), and ethyl O-beta-(6'-galloyl)-glucopyranoside (3), together with eleven known ones, were isolated from the stem bark of Trewia nudiflora. Their structures were elucidated by means of I D, 2 D NMR and HR-MS analyses. The antioxidant activities of these compounds were evaluated with the DPPH radical-scavenging assay. Compound 1 showed significant antioxidant activity. In addition, compounds 1, 2 and 3 rescued the H2O2-induced PC12 cell death at 0.4 mu M in the MTT assay.
引用
收藏
页码：445 / 448
页数：4
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