Enzymatic synthesis and antiviral activity of 2'-deoxy-2'-fluoro-ribavirin

被引：8

作者：

Slater, MJ ^{[1
]}

Gowrie, C ^{[1
]}

Freeman, GA ^{[1
]}

Short, SA ^{[1
]}

机构：

[1] GLAXO WELLCOME INC,RES,RES TRIANGLE PK,NC 27709

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00514-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2'-Deoxy-2'-fluoro-ribavirin has been efficiently synthesised from 2'-deoxy-2'-fluorouridine using nucleoside transferase as the key step, and evaluated for its antiviral properties in cell culture. An efficient synthesis of 3,5-di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-beta-D-ribofuranose is also described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2787 / 2790

页数：4

共 50 条

[41] SYNTHESIS OF 2'-DEOXY-2'-FLUORO-D-ARABINOPYRANOSYL NUCLEOSIDES AND THEIR 3',4'-SECO ANALOGS
HERDEWIJN, P
VANAERSCHOT, A
BUSSON, R
CLAES, P
DECLERCQ, E
NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (07): : 1525 - 1549
[42] SYNTHESIS OF 2'-DEOXY-2'(S)-DEUTERIO AND 2'-DEOXY-2'(R)-DEUTERIO-BETA-D-NUCLEOSIDES
PATHAK, T
BAZIN, H
CHATTOPADHYAYA, J
TETRAHEDRON, 1986, 42 (19) : 5427 - 5441
[43] TOTAL SYNTHESIS OF 2'-DEOXY-2'-ARAFLUORO-TUBERCIDIN, 2'-DEOXY-2'-ARAFLUORO-TOYOCAMYCIN, 2'-DEOXY-2'-ARAFLUORO-SANGIVAMYCIN AND CERTAIN RELATED NUCLEOSIDES
BHATTACHARYA, BK
RAO, TS
REVANKAR, GR
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (12): : 1543 - 1550
[44] Synthesis and crystal structure of 2′-deoxy-2′-fluoro-4′-thioribonucleosides:: substrates for the synthesis of novel modified RNAs
Takahashi, Mayumi
Daidouji, Shunsuke
Shiro, Motoo
Minakawa, Noriaki
Matsuda, Akira
TETRAHEDRON, 2008, 64 (19) : 4313 - 4324
[45] 2′-deoxy-2′-C-trifluoromethyl β-D-ribonucleoside analogues:: Synthesis and antiviral evaluations
Jeannot, F
Gosselin, G
Mathé, C
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2003, 22 (5-8): : 857 - 859
[46] POLY-2'-DEOXY-2'-FLUORO-CYTIDYLIC ACID - ENZYMATIC-SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND INTERACTION WITH POLY-INOSINIC ACID
GUSCHLBAUER, W
BLANDIN, M
DROCOURT, JL
THANG, MN
NUCLEIC ACIDS RESEARCH, 1977, 4 (06) : 1933 - 1943
[47] REGIOSPECIFIC SYNTHESIS OF 2'-DEOXY-2',2''-DIDEUTERIO NUCLEOSIDES
WU, JC
BAZIN, H
CHATTOPADHYAYA, J
TETRAHEDRON, 1987, 43 (10) : 2355 - 2368
[48] THE CRYSTAL-STRUCTURES OF 2'-DEOXY-2'-FLUOROCYTIDINE AND 2'-DEOXY-2'-FLUOROURIDINE
MARCK, C
LESYNG, B
SAENGER, W
JOURNAL OF MOLECULAR STRUCTURE, 1982, 82 (1-2) : 77 - 94
[49] RNase A-catalyzed synthesis of dinucleotides containing 2' -deoxy-2' -fluoro-pyrimidinenucleosides at 3'-termini
陈耀全
丁天忠
汪猷
Science Bulletin, 1995, (04) : 307 - 309
[50] Synthesis of dinucleoside, di(2'-deoxy-2'-fluoro)nucleoside phosphates and phosphorothioates and their stability to snake venom phosphodiesterase
Wang, ZF
Gu, XH
Chen, YQ
CHINESE JOURNAL OF CHEMISTRY, 1996, 14 (01) : 80 - 86

← 1 2 3 4 5 →