Enzymatic synthesis and antiviral activity of 2'-deoxy-2'-fluoro-ribavirin

被引：8
|
作者：
Slater, MJ [1 ]
Gowrie, C [1 ]
Freeman, GA [1 ]
Short, SA [1 ]
机构：
[1] GLAXO WELLCOME INC,RES,RES TRIANGLE PK,NC 27709
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期
关键词：
D O I：
10.1016/S0960-894X(96)00514-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2'-Deoxy-2'-fluoro-ribavirin has been efficiently synthesised from 2'-deoxy-2'-fluorouridine using nucleoside transferase as the key step, and evaluated for its antiviral properties in cell culture. An efficient synthesis of 3,5-di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-beta-D-ribofuranose is also described. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：2787 / 2790
页数：4
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