Microwave-assisted [3+2] cycloadditions of azomethine ylides

被引：52

作者：

Bashiardes, G ^{[1
]}

Safir, I ^{[1
]}

Mohamed, AS ^{[1
]}

Barbot, F ^{[1
]}

Laduranty, J ^{[1
]}

机构：

[1] Univ Poitiers, SFA UMR 6514, Dept Chim Methodol & Synth Biomol, F-86022 Poitiers, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 25期

关键词：

D O I：

10.1021/ol0361195

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The microwave-assisted intramolecular [3 + 2] cycloaddition reaction of azomethine ylides to activated and nonactivated alkenes and alkynes is described. The procedure allows the synthesis of pyrrolidines and pyrrole products in good to excellent overall yields in short reaction times. It appears from parallel comparative studies that the microwave procedure favors the reaction times and overall purity of the crude reaction mixture. The reactions can also be performed in the absence of solvent.

引用

页码：4915 / 4918

页数：4

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