Highly Regio- and Stereoselective Three-Component Nickel-Catalyzed syn-Hydrocarboxylation of Alkynes with Diethyl Zinc and Carbon Dioxide

被引：184
|
作者：
Li, Suhua [1 ]
Yuan, Weiming [2 ]
Ma, Shengming [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 11期
基金：
中国国家自然科学基金;
关键词：
alkynes; carbon dioxide; hydrocarboxylation; inorganic fluoride; nickel; NICKEL(0)-MEDIATED SEQUENTIAL ADDITION; TYROSINE KINASE INHIBITORS; METHYLENE-GAMMA-LACTAMS; UNSATURATED-HYDROCARBONS; ARYLATIVE CARBOXYLATION; ALKENYLBORONIC ESTERS; CYTOTOXIC EVALUATION; ORGANOZINC REAGENTS; ALLYL STANNANES; CO2;
D O I：
10.1002/anie.201007128
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrocarboxylation of alkynes: The first example of nickel-catalyzed hydrozincation of alkynes that form stereodefined hydrocarboxylation products is presented (see scheme; cod=cycloocta-1,5-diene). This catalytic system is efficient for the activation of CO2 and the three-component reaction produces products that could be converted into important oxindole or γ-butyrolactam derivatives. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2578 / 2582
页数：5
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