The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (West Africa) is associated with low frequencies of classic malaria-resistance genes

被引:74
|
作者
Modiano, D
Luoni, G
Sirima, BS
Lanfrancotti, A
Petrarca, V
Cruciani, F
Simporé, J
Ciminelli, BM
Foglietta, E
Grisanti, P
Bianco, I
Modiano, G
Coluzzi, M
机构
[1] Univ La Sapienza, Ist Parassitol, WHO Collaborating Ctr Malaria Epidemiol, I-00185 Rome, Italy
[2] Univ La Sapienza, Ist Parassitol, Fdn Pasteur Cenci Bolognetti, I-00185 Rome, Italy
[3] Univ La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy
[4] Univ Roma Tor Vergata, Dipartimento Biol, Rome, Italy
[5] Assoc Nazl Lotta Contro Microcitemie Italia, Rome, Italy
[6] Univ Camerino, Dipartimento Biol Mol Cellulare & Anim, I-62032 Camerino, Italy
[7] Minist Affari Esteri, Direzione Gen Cooperaz Sviluppo, Rome, Italy
[8] Minist Saude, Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
[9] Ctr MEd St Camille, Ouagadougou, Burkina Faso
关键词
malaria; Plasmodium falciparum; disease susceptibility; genes; ethnic differences; haemoglobinopathy; glucose 6-phosphate dehydrogenase deficiency; Burkina Faso;
D O I
10.1016/S0035-9203(01)90141-5
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The gene frequencies in 1993-94 for haemoglobin S, haemoglobin C, alpha(-3.7) deletional thalassaemia, G6PDA(-), HLA B*5301 were estimated in Fulani, Mossi and Rimaibe ethnic groups of Burkina Faso, West Africa. The aim of the study was to verify whether the previously reported Fulani lower susceptibility to Plasmodium falciparum malaria was associated with any of these malaria-resistance genes. Similar frequencies for haemoglobin S were recorded in the 3 ethnic groups (0.024 +/- 0.008, 0030 +/- 0.011, 0.022 +/- 0.013; in Mossi, Rimaibe and Fulani, respectively). The Mossi and Rimaibe showed higher frequencies when compared to Fulani for haemoglobin C (0.117 +/- 0.018, 0.127 +/- 0.020, 0.059 +/- 0.020), alpha(-3.7) deletional thalassaemia (0.227 +/- 0.040, 0.134 +/- 0.032, 0.103 +/- 0.028), G6PDA(-) (0.196 +/- 0.025, 0.187 +/- 0.044, 0.069 +/- 0.025) and HLA B*5301 (0.189 +/- 0.038, 0.202 +/- 0.041, 0.061 +/- 0.024). Among Fulani the proportion of individuals not having any of these protective alleles was more than 3-fold greater than in the Mossi-Rimaibe group (56.8% vs 16.7%; P < 0.001). These findings exclude the involvement of these generic factors of resistance to P. falciparum in the lower susceptibility to malaria of Fulani. This evidence, in association with the previously reported higher immune reactivity to malaria of Fulani, further supports the existence in this ethnic group of unknown genetic factor(s) of resistance to malaria probably involved in the regulation of humoral immune responses.
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页码:149 / +
页数:5
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