Malaria cure with sulphadoxine/pyrimethamine combination in 12 semi-immune adults from West-Central Africa with high rates of point mutations in Plasmodium falciparum dhfr and dhps genes

被引：8

作者：

Berzosa, PJ

Puente, S

Benito, A

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Parasitol, Lab Malaria, Madrid 28220, Spain

[2] Hosp Carlos III CAM, Unidad Med Trop, Madrid 28220, Spain

[3] Inst Salud Carlos III, Ctr Nacl Med Trop, Madrid 28220, Spain

来源：

PARASITOLOGY RESEARCH | 2005年 / 97卷 / 04期

关键词：

D O I：

10.1007/s00436-005-1424-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We report 12 uncomplicated falciparum-malaria cases from semi-immune people from Central Africa treated with sulfadoxine/pyrimethamine (Fansidar) in a Spanish hospital. We resolved by PCR-RFLP the mutations in dhfr and dhps genes related to resistance to antifolate drugs. The 12 patients presented high frequencies of combined mutations in both genes but they were completely cured after treatment.

引用

页码：287 / 289

页数：3