Antitumor agents.: Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system

被引：28

作者：

Capilla, AS

Sánchez, I

Caignard, DH

Renard, P

Pujol, MD

机构：

[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, E-08028 Barcelona, Spain

[2] Lab Adir, F-92415 Courbevoie, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 36卷 / 04期

关键词：

1,4-benzodioxin; naphtho-fused systems; antitumor agents;

D O I：

10.1016/S0223-5234(01)01231-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New compounds with naphtho-fused systems were synthesized and evaluated as antitumor agents. The naphtho-fused systems 6 and 7, synthesized from the hydroxy-acetal, exhibit antirumor activity. The bis(phenylthio) derivatives were considered as possible precursors for lignan lactones (11). The hydroxy-naphthalen 6 showed a significant antineoplastic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：389 / 393

页数：5

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