Antitumor agents.: Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system

被引：28
|
作者：
Capilla, AS
Sánchez, I
Caignard, DH
Renard, P
Pujol, MD
机构：
[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, E-08028 Barcelona, Spain
[2] Lab Adir, F-92415 Courbevoie, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 36卷 / 04期
关键词：
1,4-benzodioxin; naphtho-fused systems; antitumor agents;
D O I：
10.1016/S0223-5234(01)01231-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New compounds with naphtho-fused systems were synthesized and evaluated as antitumor agents. The naphtho-fused systems 6 and 7, synthesized from the hydroxy-acetal, exhibit antirumor activity. The bis(phenylthio) derivatives were considered as possible precursors for lignan lactones (11). The hydroxy-naphthalen 6 showed a significant antineoplastic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：389 / 393
页数：5
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