Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

被引：40

作者：

Liu, Mengyang ^{[1
]}

Chen, Zhe ^{[1
]}

Zabihian, Behrooz ^{[1
]}

Sinz, Christoph ^{[2
]}

Zhang, Edward ^{[3
]}

Beard, Paul C. ^{[3
]}

Ginner, Laurin ^{[1
]}

Hoover, Erich ^{[4
]}

Minneman, Micheal P. ^{[4
]}

Leitgeb, Rainer A. ^{[1
]}

Kittler, Harald ^{[2
]}

Drexlerv, Wolfgang ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Med Phys & Biomed Engn, Wahringer Gurtel 18-20,AKH 4L, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Dermatol, Wahringer Gurtel 18-20,AKH 7J, A-1090 Vienna, Austria

[3] UCL, Dept Med Phys & Biomed Engn, Gower St, London WC1E 6BT, England

[4] INSIGHT Photon Solut Inc, 300 S Publ Rd, Lafayette, CO 80026 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 09期

关键词：

ANGIOGENESIS; ULTRASOUND; TISSUES;

D O I：

10.1364/BOE.7.003390

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive human skin vasculature and morphology imaging in vivo. (C) 2016 Optical Society of America

引用

页码：3390 / 3402

页数：13

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