Leptosins O-S, cytotoxic metabolites of a strain of Leptosphaeria sp isolated from a marine alga

被引：31
|
作者：
Yamada, T [1 ]
Iwamoto, C [1 ]
Yamagaki, N [1 ]
Yamanouchi, T [1 ]
Minoura, K [1 ]
Hagishita, S [1 ]
Numata, A [1 ]
机构：
[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan
来源：
HETEROCYCLES | 2004年 / 63卷 / 03期
关键词：
D O I：
10.3987/COM-03-9967
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Leptosins O (1), P (2), Q (3), R (4) and S (5) have been isolated from a strain of Leptosphaeria sp. originally separated from the marine alga Sargassum tortile. Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses of their acetate derivatives (6-10) using various 1D and 2D NMR techniques and some chemical transformations. The NMR and NOE spectral analyses of 6-10 revealed that they exist in a single conformer of B type in CDCl3. Among these metabolites, leptosins O (1) and P (2) exhibited significant cytotoxicity against cultured P388 cells
引用
收藏
页码：641 / 653
页数：13
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