Leptosins O-S, cytotoxic metabolites of a strain of Leptosphaeria sp isolated from a marine alga

被引：31

作者：

Yamada, T ^{[1
]}

Iwamoto, C ^{[1
]}

Yamagaki, N ^{[1
]}

Yamanouchi, T ^{[1
]}

Minoura, K ^{[1
]}

Hagishita, S ^{[1
]}

Numata, A ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

来源：

HETEROCYCLES | 2004年 / 63卷 / 03期

关键词：

D O I：

10.3987/COM-03-9967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Leptosins O (1), P (2), Q (3), R (4) and S (5) have been isolated from a strain of Leptosphaeria sp. originally separated from the marine alga Sargassum tortile. Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses of their acetate derivatives (6-10) using various 1D and 2D NMR techniques and some chemical transformations. The NMR and NOE spectral analyses of 6-10 revealed that they exist in a single conformer of B type in CDCl3. Among these metabolites, leptosins O (1) and P (2) exhibited significant cytotoxicity against cultured P388 cells

引用

页码：641 / 653

页数：13

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