Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

被引：5

作者：

Zhang, Ju ^{[1
,2
]}

Ding, Nan ^{[1
,2
]}

Song, Yangzi ^{[1
,2
]}

Song, Rui ^{[1
]}

Pan, Yang ^{[3
]}

Wang, Linghang ^{[1
,2
]}

Yan, Shuo ^{[1
]}

Wang, Qi ^{[1
]}

Ma, Shanfang ^{[1
]}

Wei, Lirong ^{[1
]}

Yu, Fengting ^{[1
,2
]}

Lu, Lianhe ^{[1
]}

Zhang, Fujie ^{[1
,2
]}

Chen, Chen ^{[1
,2
]}

Zeng, Hui ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China

[2] Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China

[3] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China

来源：

INNOVATION | 2021年 / 2卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SARS-CoV-2; COVID-19; asymptomatic transmission; outbreak; phylogenomic; CORONAVIRUS; ALIGNMENT; CHINA;

D O I：

10.1016/j.xinn.2021.100099

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.

引用

页数：7

共 50 条

[41] COVID-19: An Asymptomatic Carrier
Patel, S.
Patel, F.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)
[42] An Asymptomatic Patient with COVID-19
Zhang, Jingping
Du, Yonghao
Pu, Jiantao
Jin, Chenwang
Yang, Jian
Guo, Youmin
Bai, Lu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (11) : 1428 - 1429
[43] COVID-19 Outbreak in Malaysia
Elengoe, Asita
OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES, 2020, 11 (03) : 93 - 100
[44] COVID-19 Outbreak and Dentistry
Carmona, Jessie Reyes
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES, 2020, 22 (02) : 9 - 9
[45] The outbreak of COVID-19: An overview
Wu, Yi-Chi
Chen, Ching-Sung
Chan, Yu-Jiun
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2020, 83 (03) : 217 - 220
[46] COVID-19 Outbreak: An Overview
Ciotti, Marco
Angeletti, Silvia
Minieri, Marilena
Giovannetti, Marta
Benvenuto, Domenico
Pascarella, Stefano
Sagnelli, Caterina
Bianchi, Martina
Bernardini, Sergio
Ciccozzi, Massimo
CHEMOTHERAPY, 2020, 64 (5-6) : 215 - 223
[47] The COVID-19 outbreak in Iran
Salimi, Rasoul
Gomar, Reza
Heshmati, Bahram
JOURNAL OF GLOBAL HEALTH, 2020, 10 (01)
[48] COVID-19 Outbreak in Istanbul
Aykac, Nilufer
Elbek, Osman
TURKISH THORACIC JOURNAL, 2022, 23 (01): : 63 - 69
[49] COVID-19 Outbreak and Turkey
Elbek, Osman
TURKISH THORACIC JOURNAL, 2020, 21 (03): : 215 - 216
[50] Dentistry and the COVID-19 Outbreak
Amante, Luis Filipe Lima Sobral
Afonso, Joao Torres Monteiro
Skrupskelyte, Greta
INTERNATIONAL DENTAL JOURNAL, 2021, 71 (05) : 358 - 368

← 1 2 3 4 5 →