Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

被引：5

作者：

Zhang, Ju ^{[1
,2
]}

Ding, Nan ^{[1
,2
]}

Song, Yangzi ^{[1
,2
]}

Song, Rui ^{[1
]}

Pan, Yang ^{[3
]}

Wang, Linghang ^{[1
,2
]}

Yan, Shuo ^{[1
]}

Wang, Qi ^{[1
]}

Ma, Shanfang ^{[1
]}

Wei, Lirong ^{[1
]}

Yu, Fengting ^{[1
,2
]}

Lu, Lianhe ^{[1
]}

Zhang, Fujie ^{[1
,2
]}

Chen, Chen ^{[1
,2
]}

Zeng, Hui ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China

[2] Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China

[3] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China

来源：

INNOVATION | 2021年 / 2卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SARS-CoV-2; COVID-19; asymptomatic transmission; outbreak; phylogenomic; CORONAVIRUS; ALIGNMENT; CHINA;

D O I：

10.1016/j.xinn.2021.100099

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.

引用

页数：7

共 50 条

[21] Asymptomatic Children as a Missing Link in Preventing COVID-19 Transmission
Sedighi, Iraj
Raeisi, Roya
Amiri, Jalaleddin
Shalchi, Zohreh
Karami, Manoochehr
Jalilian, Farid Azizi
Teimoori, Ali
Ansari, Nastaran
Bathaei, Jalaledin
Hashemi, Mohammad
JOURNAL OF RESEARCH IN HEALTH SCIENCES, 2024, 24 (02)
[22] Asymptomatic COVID-19 infection: diagnosis, transmission, population characteristics
You, Yaxian
Yang, Xinyuan
Hung, Dongni
Yang, Qianxi
Wu, Ting
Deng, Meichun
BMJ SUPPORTIVE & PALLIATIVE CARE, 2021, : E220 - E227
[23] Asymptomatic COVID-19 in South Africa - implications for the control of transmission
Paleker, M.
Tembo, Y. A.
Davies, M-A
Mahomed, H.
Pienaar, D.
Madhi, S. A.
McCarthy, K.
PUBLIC HEALTH ACTION, 2021, 11 (02): : 58 - 60
[24] COVID-19 transmission through asymptomatic carriers is a challenge to containment
Yu, Xingxia
Yang, Rongrong
INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2020, 14 (04) : 474 - 475
[25] The role of asymptomatic class, quarantine and isolation in the transmission of COVID-19
Ali, Mohsin
Shah, Syed Touqeer H.
Imran, Mudassar
Khan, Adnan
JOURNAL OF BIOLOGICAL DYNAMICS, 2020, 14 (01) : 389 - 408
[26] Asymptomatic COVID-19 transmission: the importance of avoiding official miscommunication
Lippi, Giuseppe
Plebani, Mario
DIAGNOSIS, 2020, 7 (04) : 347 - 348
[27] Modeling of Vaccination and Contact Tracing as Tools to Control the COVID-19 Outbreak in Spain
Angels Colomer, Ma
Margalida, Antoni
Alos, Francesc
Oliva-Vidal, Pilar
Vilella, Anna
Fraile, Lorenzo
VACCINES, 2021, 9 (04)
[28] Contact tracing with digital assistance in Taiwan's COVID-19 outbreak response
Jian, Shu-Wan
Cheng, Hao-Yuan
Huang, Xiang-Ting
Liu, Ding-Ping
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 101 : 348 - 352
[29] The secondary transmission pattern of COVID-19 based on contact tracing in Rwanda
Semakula, Muhammed
Niragire, FranCois
Umutoni, Angela
Nsanzimana, Sabin
Ndahindwa, Vedaste
Rwagasore, Edison
Nyatanyi, Thierry
Remera, Eric
Faes, Christel
BMJ GLOBAL HEALTH, 2021, 6 (06):
[30] Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics
Gardner, Billy J.
Kilpatrick, A. Marm
PLOS COMPUTATIONAL BIOLOGY, 2021, 17 (06)

← 1 2 3 4 5 →