Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

被引：5

作者：

Zhang, Ju ^{[1
,2
]}

Ding, Nan ^{[1
,2
]}

Song, Yangzi ^{[1
,2
]}

Song, Rui ^{[1
]}

Pan, Yang ^{[3
]}

Wang, Linghang ^{[1
,2
]}

Yan, Shuo ^{[1
]}

Wang, Qi ^{[1
]}

Ma, Shanfang ^{[1
]}

Wei, Lirong ^{[1
]}

Yu, Fengting ^{[1
,2
]}

Lu, Lianhe ^{[1
]}

Zhang, Fujie ^{[1
,2
]}

Chen, Chen ^{[1
,2
]}

Zeng, Hui ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China

[2] Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China

[3] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China

来源：

INNOVATION | 2021年 / 2卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SARS-CoV-2; COVID-19; asymptomatic transmission; outbreak; phylogenomic; CORONAVIRUS; ALIGNMENT; CHINA;

D O I：

10.1016/j.xinn.2021.100099

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles' heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.

引用

页数：7

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