Assessment of Rodents as Animal Models for Reston Ebolavirus

被引：16

作者：

de Wit, Emmie

Munster, Vincent J.

Metwally, Samia A. ^{[2
]}

Feldmann, Heinz ^{[1
]}

机构：

[1] NIAID, Virol Lab, Div Intramural Res, NIH,Rocky Mt Labs, Hamilton, MT 59840 USA

[2] USDA, Food & Agr Org Reference Ctr Vesicular Dis, Anim & Plant Hlth Inspect Serv,Foreign Anim Dis D, Natl Vet Serv Labs,Plum Isl Anim Dis Ctr, Greenport, NY USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷

基金：

美国国家卫生研究院;

关键词：

MOUSE MODEL; VIRUS; PHILIPPINES; HOST;

D O I：

10.1093/infdis/jir330

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-/-) mice may be used for research of REBOV pathogenicity and intervention strategies.

引用

页码：S968 / S972

页数：5

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