Assessment of Rodents as Animal Models for Reston Ebolavirus

被引：16
|
作者：
de Wit, Emmie
Munster, Vincent J.
Metwally, Samia A. [2 ]
Feldmann, Heinz [1 ]
机构：
[1] NIAID, Virol Lab, Div Intramural Res, NIH,Rocky Mt Labs, Hamilton, MT 59840 USA
[2] USDA, Food & Agr Org Reference Ctr Vesicular Dis, Anim & Plant Hlth Inspect Serv,Foreign Anim Dis D, Natl Vet Serv Labs,Plum Isl Anim Dis Ctr, Greenport, NY USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷
基金：
美国国家卫生研究院;
关键词：
MOUSE MODEL; VIRUS; PHILIPPINES; HOST;
D O I：
10.1093/infdis/jir330
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-/-) mice may be used for research of REBOV pathogenicity and intervention strategies.
引用
收藏
页码：S968 / S972
页数：5
相关论文
共 50 条
  • [21] Early Life Stress in Rodents: Animal Models of Illness or Resilience?
    Murthy, Sahana
    Gould, Elizabeth
    FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2018, 12
  • [22] Animal models for allergenicity assessment
    Kimber, I
    TOXICOLOGY, 2002, 178 (01) : 27 - 27
  • [23] Frailty Assessment in Animal Models
    Heinze-Milne, Stefan D.
    Banga, Shubham
    Howlett, Susan E.
    GERONTOLOGY, 2019, 65 (06) : 610 - 619
  • [24] Optimization of IgG-ELISA and molecular analysis of Reston-ebolavirus among swine in Northern Luzon, the Philippines
    Yusuke, S.
    Shuetsu, F.
    Mariko, S.
    Demetria, C.
    Itoe, I.
    Tetsuya, M.
    Masayuki, S.
    Momoko, O.
    Akira, S.
    Lupisan, S.
    Ichiro, K.
    Olveda, R.
    Hitoshi, O.
    Shigeru, M.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 : E459 - E459
  • [25] Early life stress paradigms in rodents: potential animal models of depression?
    Schmidt, Mathias V.
    Wang, Xiao-Dong
    Meijer, Onno C.
    PSYCHOPHARMACOLOGY, 2011, 214 (01) : 131 - 140
  • [26] Preclinical imaging and treatment of cancer: the use of animal models beyond rodents
    Axiak-Bechtel, S. M.
    Maitz, C. A.
    Selting, K. A.
    Bryan, J. N.
    QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 59 (03): : 303 - 316
  • [27] Early life stress paradigms in rodents: potential animal models of depression?
    Mathias V. Schmidt
    Xiao-Dong Wang
    Onno C. Meijer
    Psychopharmacology, 2011, 214 : 131 - 140
  • [28] Diurnal rodents as pertinent animal models of human retinal physiology and pathology
    Verra, Daniela M.
    Sajdak, Benjamin S.
    Merriman, Dana K.
    Hicks, David
    PROGRESS IN RETINAL AND EYE RESEARCH, 2020, 74
  • [29] Animal models of Parkinson's disease in rodents induced by toxins:: an update
    Hirsch, EC
    Höglinger, G
    Rousselet, E
    Breidert, T
    Parain, K
    Feger, J
    Ruberg, M
    Prigent, A
    Cohen-Salmon, C
    Launay, JM
    JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, 2003, (65): : 89 - 100
  • [30] Animal models of Parkinson's disease in rodents induced by toxins:: an update
    Hirsch, EC
    Höglinger, G
    Rousselet, E
    Breidert, T
    Parain, K
    Feger, J
    Ruberg, M
    Prigent, A
    Cohen-Salmon, C
    Launay, JM
    ADVANCES IN RESEARCH ON NEURODEGENERATION, 2003, 10 : 89 - 100
12345