Assessment of Rodents as Animal Models for Reston Ebolavirus

被引：16
|
作者：
de Wit, Emmie
Munster, Vincent J.
Metwally, Samia A. [2 ]
Feldmann, Heinz [1 ]
机构：
[1] NIAID, Virol Lab, Div Intramural Res, NIH,Rocky Mt Labs, Hamilton, MT 59840 USA
[2] USDA, Food & Agr Org Reference Ctr Vesicular Dis, Anim & Plant Hlth Inspect Serv,Foreign Anim Dis D, Natl Vet Serv Labs,Plum Isl Anim Dis Ctr, Greenport, NY USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷
基金：
美国国家卫生研究院;
关键词：
MOUSE MODEL; VIRUS; PHILIPPINES; HOST;
D O I：
10.1093/infdis/jir330
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-/-) mice may be used for research of REBOV pathogenicity and intervention strategies.
引用
收藏
页码：S968 / S972
页数：5
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