Role of SIRT1 in the neuroprotective effects of resveratrol on MPP+-induced apoptosis in neurons

被引：0

作者：

Alvira, D. ^{[1
]}

Yeste-Velasco, M. ^{[1
]}

Folch, J. ^{[2
]}

Verdaguer, E.

Rimbau, V. ^{[1
]}

Canudas, A. M. ^{[1
]}

Pallas, M. ^{[1
]}

Camins, A. ^{[1
]}

机构：

[1] Univ Barcelona, Unitat Farmacol & Farmacognosia, Inst Biomed, Fac Farm, E-08028 Barcelona, Spain

[2] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Bioquim, Reus, Spain

来源：

NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2007 | 2007年

关键词：

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We study the role of the mammalian silent information regulator 2 (SIRT1) in the process of neuroprotection mediated by resveratrol MPP+-induced loss of cell viability and apoptosis in CGNs was prevented by the addition of RESV (1 mu M to 100 mu M). However, the neuroprotective effects were not mediated by the activation of SIRT1, since sirtinol -an inhibitor of this enzyme- did not attenuate them. Furthermore MPP+ decreases the protein expression of SIRT1. Our results indicate that the antiapoptotic effects of RESV in MPP+ are independent of the stimulation of SIRT1 and depend on its antioxidant properties.

引用

页码：185 / +

页数：2

共 50 条

[31] Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
Xia, Ning
Strand, Susanne
Schlufter, Frank
Siuda, Daniel
Reifenberg, Gisela
Kleinert, Hartmut
Foerstermann, Ulrich
Li, Huige
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2013, 32 : 29 - 35
[32] Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function
Nishigaki, Akemi
Tsubokura, Hiroaki
Tsuzuki-Nakao, Tomoko
Okada, Hidetaka
REPRODUCTIVE MEDICINE AND BIOLOGY, 2022, 21 (01)
[33] Neuroprotective effects of saikosaponin-d on MPP+-induced cytotoxicity in SH-SY5Y cells via regulation of SIRT3
Yang, Jun
Li, Cheng-Yan
Zhang, Gui-Bin
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (03): : 5821 - 5827
[34] Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP+-induced oxidative stress
Wu, Xian
Ren, Yixian
Wen, Yue
Lu, Sixin
Li, Huihui
Yu, Honglin
Li, Wenjun
Zou, Fei
FREE RADICAL BIOLOGY AND MEDICINE, 2022, 181 : 82 - 97
[35] Neuronal Sirt1 is Required for Resveratrol Preconditioning Induced Ischemic Tolerance
Koronowski, Kevin B.
Saul, Isa
Balmuth-Loris, Zachary
Perez-Pinzon, Miguel
STROKE, 2017, 48
[36] Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
Fujino, Kotaro
Ogura, Yurina
Sato, Kazunori
Nedachi, Taku
NEUROSCIENCE LETTERS, 2013, 557 : 148 - 153
[37] The neuroprotective effects of paeoniflorin against MPP+-induced damage to dopaminergic neurons via the Akt/Nrf2/GPX4 pathway
Wang, Lufeng
An, Hedi
Yu, Fei
Yang, Jie
Ding, Hao
Bao, Yiwen
Xie, Hongrong
Huang, Dongya
JOURNAL OF CHEMICAL NEUROANATOMY, 2022, 122
[38] The neuroprotective effect of lovastatin on MPP+-induced neurotoxicity is not mediated by PON2
Aguirre-Vidal, Yoshajandith
Montes, Sergio
Tristan-Lopez, Luis
Anaya-Ramos, Laura
Teiber, John
Rios, Camilo
Baron-Flores, Veronica
Monroy-Noyola, Antonio
NEUROTOXICOLOGY, 2015, 48 : 166 - 170
[39] Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?
Grzeczka, Arkadiusz
Kordowitzki, Pawel
NUTRIENTS, 2022, 14 (23)
[40] Activation of SIRT1 by Resveratrol requires lamin A
Liu, Baohua
Zhou, Zhongjun
AGING-US, 2013, 5 (02): : 94 - 95

← 1 2 3 4 5 →