Role of SIRT1 in the neuroprotective effects of resveratrol on MPP+-induced apoptosis in neurons

We study the role of the mammalian silent information regulator 2 (SIRT1) in the process of neuroprotection mediated by resveratrol MPP+-induced loss of cell viability and apoptosis in CGNs was prevented by the addition of RESV (1 mu M to 100 mu M). However, the neuroprotective effects were not mediated by the activation of SIRT1, since sirtinol -an inhibitor of this enzyme- did not attenuate them. Furthermore MPP+ decreases the protein expression of SIRT1. Our results indicate that the antiapoptotic effects of RESV in MPP+ are independent of the stimulation of SIRT1 and depend on its antioxidant properties.