Role of SIRT1 in the neuroprotective effects of resveratrol on MPP+-induced apoptosis in neurons

被引：0

作者：

Alvira, D. ^{[1
]}

Yeste-Velasco, M. ^{[1
]}

Folch, J. ^{[2
]}

Verdaguer, E.

Rimbau, V. ^{[1
]}

Canudas, A. M. ^{[1
]}

Pallas, M. ^{[1
]}

Camins, A. ^{[1
]}

机构：

[1] Univ Barcelona, Unitat Farmacol & Farmacognosia, Inst Biomed, Fac Farm, E-08028 Barcelona, Spain

[2] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Bioquim, Reus, Spain

来源：

NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2007 | 2007年

关键词：

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We study the role of the mammalian silent information regulator 2 (SIRT1) in the process of neuroprotection mediated by resveratrol MPP+-induced loss of cell viability and apoptosis in CGNs was prevented by the addition of RESV (1 mu M to 100 mu M). However, the neuroprotective effects were not mediated by the activation of SIRT1, since sirtinol -an inhibitor of this enzyme- did not attenuate them. Furthermore MPP+ decreases the protein expression of SIRT1. Our results indicate that the antiapoptotic effects of RESV in MPP+ are independent of the stimulation of SIRT1 and depend on its antioxidant properties.

引用

页码：185 / +

页数：2

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