The SPECTRA Study: A Phase 2a Single-Arm, Open-Label, Multicenter Exploratory Study to Assess the Effects of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)

被引：0
|
作者：
Waxman, A. B. [1 ]
Risbano, M. G. [2 ]
Frantz, R. P. [3 ]
Manimaran, S. [4 ]
Lu, J. [4 ]
Rischard, F. [5 ]
机构：
[1] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
[2] Univ Pittsburgh, Pittsburgh, PA USA
[3] Mayo Clin, Rochester, NY USA
[4] Acceleron Pharma, Cambridge, MA USA
[5] Univ Arizona, Tucson, AZ USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2021年 / 203卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A1187
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Results Of The Prospective, Multicenter, Single-Arm, Open-Label, Phase 4 Motion Study Of Riociguat In Pulmonary Arterial Hypertension
    Sood, N.
    Aranda, A.
    Platt, D. M.
    LaRose, A.
    Kleinjung, F.
    O'Brien, G.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
  • [2] Baseline Demographics Of The Prospective, Multicenter, Single-Arm, Open-Label, Phase Iv Motion Study Of Riociguat In Pulmonary Arterial Hypertension
    Sood, N.
    Aranda, A.
    Mobin, S.
    Platt, D.
    O'Brien, G.
    Satler, C.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [3] Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension
    Humbert, Marc
    McLaughlin, Vallerie
    Gibbs, J. Simon R.
    Gomberg-Maitland, Mardi
    Hoeper, Marius M.
    Preston, Ioana R.
    Souza, Rogerio
    Waxman, Aaron B.
    Ghofrani, Hossein-Ardeschir
    Subias, Pilar Escribano
    Feldman, Jeremy
    Meyer, Gisela
    Montani, David
    Olsson, Karen M.
    Manimaran, Solaiappan
    Pena, Janethe de Oliveira
    Badesch, David B.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2023, 61 (01)
  • [4] Orelabrutinib for the treatment of relapsed or refractory MCL: a phase 1/2, open-label, multicenter, single-arm study
    Deng, Li-Juan
    Zhou, Ke-Shu
    Liu, Li-Hong
    Zhang, Ming-Zhi
    Li, Zhi-Ming
    Ji, Chun-Yan
    Xu, Wei
    Liu, Ting
    Xu, Bing
    Wang, Xin
    Gao, Su-Jun
    Zhang, Hui-Lai
    Hu, Yu
    Li, Yan
    Cheng, Ying
    Yang, Hai-Yan
    Cao, Jun-Ning
    Zhu, Zun-Min
    Hu, Jian-Da
    Zhang, Wei
    Jing, Hong-Mei
    Ding, Kai-Yang
    Zhang, Xiang-Yang
    Zhao, Ren -Bin
    Zhang, Bin
    Tian, Ya -Min
    Song, Yong-Ping
    Song, Yu-Qin
    Zhu, Jun
    [J]. BLOOD ADVANCES, 2023, 7 (16) : 4349 - 4357
  • [5] PULSAR Study Open-Label Extension: Interim Results from a Phase 2 Study of the Efficacy and Safety of Sotatercept When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH)
    Badesch, D. B.
    Gibbs, S.
    Gomberg-Maitland, M.
    Hoeper, M. M.
    McLaughlin, V. V.
    Preston, I
    Souza, R.
    Waxman, A. B.
    Manimaran, S.
    Barnes, J.
    Pena, J. de Oliveira
    Humbert, M.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)
  • [6] Rationale and study design of MOTION: A phase 4, prospective, single-arm, open-label study to measure outcomes in patients with pulmonary arterial hypertension not on active treatment
    Mathai, Stephen C.
    Minai, Omar
    Sullivan, Sean D.
    Lerner, Debra
    Levine, Deborah
    [J]. RESPIRATORY MEDICINE, 2017, 122 : S23 - S27
  • [7] An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma
    Agulnik, Mark
    Schulte, Brian
    Robinson, Steven
    Hirbe, Angela C.
    Kozak, Kevin
    Chawla, Sant P.
    Attia, Steven
    Rademaker, Alfred
    Zhang, Hui
    Abbinanti, Susan
    Cehic, Rasima
    Monga, Varun
    Milhem, Mohammed
    Okuno, Scott
    Van Tine, Brian A.
    [J]. EUROPEAN JOURNAL OF CANCER, 2021, 154 : 201 - 208
  • [8] PULSAR open-label extension: interim results from a phase 2 study of the efficacy and safety of sotatercept when added to standard of care for the treatment of pulmonary arterial hypertension (PAH)
    Badesch, David
    Gibbs, Simon
    Gomberg-Maitland, Mardi
    Hoeper, Marius
    Mclaughlin, Vallerie
    Preston, Ioana
    Souza, Rogerio
    Waxman, Aaron
    Manimaran, Solaiappan
    Barnes, Jennifer
    Pena, Janethe De Oliveira
    Humbert, Marc
    Hoeper, Marius M.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [9] PULSAR Open-Label Extension: Long-Term Efficacy and Safety of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)
    Humbert, M.
    Mclaughlin, V. V.
    Gibbs, S. R.
    Gomberg-Maitland, M.
    Hoeper, M.
    Preston, I. R.
    Souza, R.
    Waxman, A. B.
    Ghofrani, H. A.
    Subias, P. Escribano
    Feldman, J. P.
    Bohns Meyer, G.
    Montani, D.
    Olsson, K. M.
    Manimaran, S.
    Pena, J. de Oliveira
    Badesch, D. B.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [10] Investigation of safety and efficacy of the new more thermostable formulation of Flolan (epoprostenol) in Japanese patients with pulmonary arterial hypertension (PAH)-An open-label, single-arm study
    Mihara, Kazuko
    Ogawa, Aiko
    Matsubara, Hiromi
    Terao, Takumi
    Ichikawa, Yoshitaka
    [J]. PLOS ONE, 2018, 13 (04):
12345