Antimicrobial activity of new coumarin derivatives

被引：1
|
作者：
Kawase, M [1 ]
Varu, B
Shah, A
Motohashi, N
Tani, S
Saito, S
Debnath, S
Mahapatra, S
Dastidar, SG
Chakrabarty, AN
机构：
[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan
[2] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India
[3] Meiji Pharmaceut Univ, Tokyo, Japan
[4] Jadavpur Univ, Dept Pharmaceut Technol, Div Microbiol, Kolkata 700032, W Bengal, India
[5] Univ Calcutta, Coll Med, Dept Med Microbiol & Parasitol, Kolkata, W Bengal, India
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2001年 / 51卷 / 01期
关键词：
coumarin derivatives; anti-Helicobacter pylori activity; antimicrobial activity; in vitro studies; synthesis;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A preliminary exploration of coumarin analogs as novel antimicrobial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The substituents ester or carboxylic acid on the coumarin ring were needed to have potent inhibitory activity against both Gram-positive and Gram-negative bacteria. The presence of phenolic hydroxyl group and/or carboxylic acid was necessary to possess higher activity against Helicobacter pylori.
引用
收藏
页码：67 / 71
页数：5
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