Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacin

被引：21
|
作者：
Vílchez, JL [1 ]
Araujo, L [1 ]
Prieto, A [1 ]
Navalón, A [1 ]
机构：
[1] Univ Granada, Fac Sci, Dept Analyt Chem, E-18071 Granada, Spain
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 26卷 / 01期
关键词：
differential-pulse voltammetry; adsorptive stripping; antibacterials; lomefloxacin;
D O I：
10.1016/S0731-7085(01)00391-0
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A differential-pulse adsorptive stripping voltammetric method for the determination of trace amounts of the antibacterial lomefloxacin is proposed, By using an accumulation potential of -0.30 V and a 2 min accumulation time, the linear concentration range of application was 1.0-10.0 ng ml(-1) of lomefloxacin. with a relative standard deviation of 3.8% (for a level of 5.0 ng ml(-1)) and a detection limit of 0.3 ng ml(-1). The method was applied to determination of lomefloxacin in human urine and serum samples. It was validated using HPLC as a reference method. Recovery levels of the method reached 100% in all cases. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：23 / 29
页数：7
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