Impairment of cognitive function and reduced hippocampal cholinergic activity in a rat model of chronic intermittent hypoxia

被引：1
|
作者：
Zhao, Chunling [1 ]
Chen, Yan [1 ]
Zhang, Chunlai [1 ]
Lue, Linya [2 ]
Xu, Qian [1 ]
机构：
[1] Luzhou Med Coll, Dept Physiol, Luzhou 646000, Sichuan Prov, Peoples R China
[2] Luzhou Med Coll, Affiliated Hosp, Dept Pediat Surg, Luzhou 646000, Sichuan Prov, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 17期
关键词：
hypoxia; brain; memory dysfunction; choline acetyl transferase; nicotinic acetylcholine receptor; chronic intermittent hypoxia; rat; neural regeneration; SPATIAL-LEARNING DEFICITS; ALZHEIMERS-DISEASE; RECEPTORS; ALPHA-7; MEMORY; PLACE;
D O I：
10.3969/j.issn.1673-5374.2011.17.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The present study established a rat model of chronic intermittent hypoxia (CIH) to simulate obstructive sleep apnea syndrome. CIH rats were evaluated for cognitive function using the Morris water maze, and neuronal pathology in the hippocampus was observed using hematoxylin-eosin staining. In addition, hippocampal choline acetyl transferase (ChAT) and nicotinic acetylcholine receptor (nAChR) expression was determined by immunohistochemistry. Our results revealed necrotic hippocampal neurons, decreased ChAT and nAChR expression, as well as cognitive impairment in CIH rats. These results suggest that hippocampal neuronal necrosis and decreased cholinergic activity may be involved in CIH-induced cognitive impairment in rats.
引用
收藏
页码：1301 / 1305
页数：5
相关论文
共 50 条
  • [41] Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment
    Liu, Fan
    Yan, Weiheng
    Chen, Chen
    Zeng, Yubing
    Kong, Yaru
    He, Xuejia
    Pei, Pei
    Wang, Shan
    Zhang, Ting
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2024, 17
  • [42] Nitric oxide deficit in chronic intermittent hypoxia impairs large conductance calcium-activated potassium channel activity in rat hippocampal neurons
    Tjong, Yung-Wui
    Li, Meifang
    Hung, Ming-Wai
    Wang, Kun
    Fung, Man-Lung
    FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (04) : 547 - 557
  • [43] Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice
    Zhang, Yichun
    Cao, Hongchao
    Qiu, Xuehao
    Xu, Danfen
    Chen, Yifeng
    Barnes, Gregory N.
    Tu, Yunjia
    Gyabaah, Adwoa Takyiwaa
    Gharbal, Abdulla Husain Abdulla Ahmed
    Peng, Chenlei
    Cai, Jun
    Cai, Xiaohong
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 14
  • [44] The Impact of Chronic Intermittent Hypoxia on Cardiac Function in Rats
    Luo, Q.
    Liu, Z. H.
    Zhao, Z. H.
    CARDIOLOGY, 2009, 114 : 61 - 61
  • [45] Effects of chronic intermittent hypoxia on endothelial function in mice
    Miller, JD
    Lund, DD
    Heistad, DD
    FASEB JOURNAL, 2006, 20 (05): : A1165 - A1165
  • [46] Reactive oxygen species mediated diaphragm fatigue in a rat model of chronic intermittent hypoxia
    Shortt, Christine M.
    Fredsted, Anne
    Chow, Han Bing
    Williams, Robert
    Skelly, J. Richard
    Edge, Deirdre
    Bradford, Aidan
    O'Halloran, Ken D.
    EXPERIMENTAL PHYSIOLOGY, 2014, 99 (04) : 688 - 700
  • [47] Proteomic sequencing analysis in a rat model of atrial fibrosis caused by chronic intermittent hypoxia
    Zhao, Bo
    Wang, Hualing
    Cheng, Lijun
    Wang, Manman
    Li, Jiao
    Gu, Tianshu
    Shangguan, Wenfeng
    Miao, Shuai
    Wang, Weiding
    Liu, Xing
    Guan, Siyu
    Liu, Tong
    Liang, Xue
    JOURNAL OF THORACIC DISEASE, 2023, 15 (10) : 5414 - 5427
  • [48] Protective Effect Of Irbesartan(arb) On Cortical Apoptosis In Rat With Chronic Intermittent Hypoxia Model
    Hung, Yu-Ju
    Lee, Shin-Da
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2015, 47 (05): : 876 - 876
  • [49] Maladaptive Pulmonary vascular responses to chronic intermittent and sustained hypoxia in a rat hypertension model
    Rocher, Asuncion
    Prieto-Lloret, Jesus
    Docio, Inmaculada
    Olea, Elena
    Llanos Bravo, Maria
    Obeso, Ana
    Gomez-Nino, Angela
    EUROPEAN RESPIRATORY JOURNAL, 2018, 52
  • [50] Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia
    Yang, Luodan
    Dong, Yan
    Wu, Chongyun
    Li, Yong
    Guo, Yichen
    Yang, Baocheng
    Zong, Xuemei
    Hamblin, Michael R.
    Liu, Timon C. -Y.
    Zhang, Quanguang
    JOURNAL OF BIOPHOTONICS, 2019, 12 (06)
12345